| Project/Area Number |
06670821
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | JICHI MEDICAL SCHOOL |
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Principal Investigator |
SASAKI Nobuhiko JICHI MEDICAL SCHOOL Pediatrics Assistant Professor, 医学部, 講師 (40225884)
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| Co-Investigator(Kenkyū-buntansha) |
ARAKAWA Youichi JICHI MEDICAL SCHOOL,Pediatrics, Assistant Professor, 医学部, 講師 (00175184)
MATSUI Akira JICHI MEDICAL SCHOOL,Pediatrics, Associate Professor, 医学部, 助教授 (00159146)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | Rotavirus / Infectious Diarrhea / Liver dysfunction / Acholic Stools / Viral Genotype |
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| Research Abstract |
Rotavirus is the most common cause of infantile dearrhea worldwide. Although most rotavirus infections are mild, they cause about 870,000 deaths each year in developing countries. Some rotavirus strains have been demonstrated to cause liver dysfunction and to grow in human liver cells. To determine which rotavirus strains cause liver dysfunction, we examined stools and serum obtained from 8 diarrheal infants (6 boys) who infected rotavirus. Rotavirus infection was diagnosed by enzyme immunoassay. Three of eight samples had a rise in serum ALT level (60IU/L<). In 3 patients ALT levels declined during convalescence. We tried but failed to isolate rotavirus from diarrheal stools and elucidate a particular genotype of the virus.
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