| Project/Area Number |
06670828
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Juntendo University School of Medicine |
|---|
Principal Investigator |
ARISAKA Osamu Juntendo University School of Medicine, Department of pediatrics, Assistant Professor, 医学部, 講師 (60151172)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HOSAKA Atsuto Juntendo University School of Medicine, Department of pediatrics, Clinical Assis, 医学部, 助手 (10238727)
SHIMURA Naoto Juntendo University School of Medicine, Department of pediatrics, Clinical Assis, 医学部, 助手 (70211290)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | Lipoprotein(a) / Phenotype / Children / Atherosclerosis / Family history / Cohort / Serum lipids / Lipoprotein(a) |
|---|
| Research Abstract |
We investigated lipoprotein (a) [Lp(a)] levels in childen and the relationship between Lp(a) and the prevalence of atherosclerotic vascular events in their families in a community. Two hundred eight-six school children and their families were entered into the study. Blood Lp(a), various lipids and apolipoproteins were measured. To determine the family history, we administered a questionnaire to the children's parents.
The distribution of Lp(a) levels in the 286 children was 0.6-106.9 mg/dl. The 95th percentile value was 50 mg/dl. There were no significant correlations between levels of Lp(a) and serum lipids / apolipoproteins(AI/B). Furthermore, we analyzed Lp(a) phenotypes in 269 children. According to the different apolipoprotein(a) electrophoretic mobilities, Lp(a) was classified into seven single-band and respective double-band phenotypes.
With regard to family history of atherosclerosis, the prevalence of coronary disease in the grandparents of children who showed Lp(a) levels of over 30 mg/dl was higher compared with those showing levels below 30 mg/dl. Also, children expressing double-band tended to have an increased incidence of coronary disease in their family. These results suggest possible relationship between the occurrence of atherosclerotic diseases in family and children's Lp(a) level.
|
