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Maturation of central motor nervous system and development of its impairment

Research Project

Project/Area Number 06670841
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKansai Medical University

Principal Investigator

YASUHARA Akihiro  Kansai Medical University, Pediatrics, Assistant Professor, 医学部, 講師 (70158004)

Co-Investigator(Kenkyū-buntansha) HATANAKA Takeshi  Kansai Medical University, Pediatrics, Assistant, 医学部, 助手 (10228471)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsmagnetic stimulation / cerebral palsy / motor evoked potential / pyramidal tract / children / somatosensory evoked potential / 磁気刺激 / 運動障害 / 誘発電位 / 発達 / 中枢運動障害
Research Abstract

Magnetic stimulation of the motor cortex (MEP) and somatosensory evoked potential (SSEP) was used to examine the central conduction time in children with cerebral palsy. Twenty-two children with cerebral palsy (14 males and 8 females), aged between 4 to 12 years, were studied. Thirteen patients had spastic diplegia, 5 spastic quadriplegia and 4 hemiplegia, respectively. All subjects were studied in the fully awake state. Informed consent was obtained from subjects and parents. A standardized examination procedure was used with the children lying supine as relaxd as possible, with electrodes attached to the abductor pollicis brevis (APB) muscle over the thenar eminence and the abductor hallucis (AH) bilaterally. Stimulation was performed using a Nihon Koden SMN-1100 magnetic stimulator with an 8 shaped stimulator coil. MEP was recorded from APB in all patients with spastic diplegia. The mean latency of MEP,i.e.36.1 msec, from APB was longer than the latency in normal controls (20.5 msec). MEP from AH was recorded by stimulation to Cz in a patient with spastic diplegia, and 8 of the 13 patients with spastic diplegia showed responses in AH according to stimulation to the cortex of hand motor area. Patients with spastic diplegia who had responses in AH was able to walk. In one of the 5 patients with spastic quadriplegia MEP in APB was recorded, and there was no response in lower extremities. Other patients with spastic quadriplegia showed no response by magnetic stimulation. In patients with hemiplegia MEP was gained by stimulation to the healthy side of the head. SSEP did not show any specific changes in patients with CP.All of subjects did not show seizure or any other side effect. MEP studies may be useful to examine the function of patients with cerebral palsy.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 田 悦: "発達にともなう誘発電位の中枢伝導時間" 脳と発達. 26. 302-307 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 安原昭博: "Sourse derivation method(SD法)によるローランド発作波の解析" 大阪てんかん研究会雑誌. 5. 29-33 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tateo Sugimoto: "When do brain abnormalities in cerebral palsy occur? An MRI study" Developmental Medicine and Child Neurology. 37. 285-292 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mieko Yamamura: "Topographic study of steady of steady-state auditory evoked potentials(SSAEPs)in humans" Neurosciences. 21. 43-52 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mieko Yamamura: "Source analysis of the auditory brainstem response using the dipole loca zing Method" Neurosciences. 21. 53-58 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mieko Yamamura: "origin of far-field N18 of SSEPs in response to mecdian nerve" Neurosciences. 21. 123-129 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 田 悦: "小児の頭部外傷性脳血管障害における誘発電位の変化について" 臨床脳波. 37. 68-73 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 安原昭博: "小児における巨大SEP群とSEP無反応群" 臨床脳波. 37. 590-592 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 安原昭博: "小児における難聴の早期発見と電気生理学的診断:小児科の立場から" 小児耳鼻咽喉科. 16. 22-26 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 安原昭博: "小児における短潜時体性感覚誘発電位" 臨床脳波. 37. 641-644 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 安原昭博: "小児における磁気刺激運動誘発電位:発達的変化と中枢運動神経系の可塑性の証明" 臨床脳波. 39. 94-98 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 北村直行: "未熟児・新生児における短潜時体性感覚誘発電位の発達" 臨床脳波. 39. 146-149 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara: "Diagnostic significance of giant SEP and absent SEP in children.Recent Advances in clinical Neurophysiology." Jun Kimura,Hiroshi Shibasaki.Elsevier, 4 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yue Tian, Akihiro Yasuhara, Atsushi Araki, Yohnosuke Kobayashi.: "Developmental changes of central conduction time of evoked potentials in infants and children" NO TO HATTATSU. 26. 302-307 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara, Atsushi Araki, Yohnosuke Kobayashi, Yamamura M.: "Analysis of rolandic discharge using the source derivation method." The Osaka Journal of Epilepsy Research. 5. 29-33 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tateo Sugimoto, Man Woo, Naoki Nishida, Atsushi Araki, Toko Hara, Akihiro Yasuhara, Yohnosuke Kobayashi, Yasuo Yamanouchi.: "When do brain abnormalities in cerebral palsy occur ? An MRI study." Developmental Medicine and Child Neurology. 37. 285-292 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mieko Yamamura, Akihiro Yasuhara, Aiko Hori: "Topographic study of steady of steady-state auditory evoked potentials (SSAEPs) in humans." Neurosciences. 21. 43-52 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mieko Yamamura, Akihiro Yasuhara, Aiko Hori: "Source analysis of the auditory brainstem response using the dipole localizing Method." Neurosciences. 21. 53-58 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mieko Yamamura, Akihiro Yasuhara, Aiko Hori: "Origin of far-field N18 of SSEPs in response to median nerve." Neurosciences. 21. 123-129 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yue Tian, Akihiro Yasuhara, Atsushi Araki, Junji Takaya, Ayako Ochi, Naoyuki Kitamura, Yohnosuke Kobayashi: "Evoked potentials in children with traumatic brain injury." Clinical Electroencephalography. 37. 68-73 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara, Ayako Ochi, Atsushi Araki, Yohnosuke Kobayashi: "Diagnostic significance of giant SEP and absent SEP in children." Clinical Electroencephalography. 37. 590-592 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara: "An early detection of hearing loss in children and electrophysiological diagnosis : An approch by Pediatrician." Pediatric Otorhinolaringology Japan. 16. 22-26 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara: "Short-latency somatosensory evoked potential in children." Clinical Electroencephalography. 37. 641-644 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara, Atsushi Araki, Ayako Ochi, Naoyuki Kitamura, Yohnosuke Kobayashi: "Diagnostic significance of giant SEP and absent SEP in children." Recent Advances in Clinical Neurophysiology Eds. Jun Kimura, Hiroshi Shibasaki. Elsevier. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara.: "Dvelopmental change and demonstration of neuronal plasticity with motor evoked potential by transcranial magnetic stimulation" Clinical Electroencephalography. 39. 94-98 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Naoyuki Kitamura, Akihiro Yasuhara, Yohnosuke Kobayashi, Atsuaki Takada, Hakuo Takahashi.: "Development of short-latency somatosensory evoked potential in infancy." Clinical Electroencephalography. 39. 146-149 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akihiro Yasuhara: "Evoked potentials." Japanese Jouranal of Pediatrics. 50. 847-854 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamamura M, et al.: "Topographic study of steady-state auditory evoked potentials (SSAEPs) in humans." Neurosciences. 21. 43-52 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamamura M, et al.: "Source analysis of the auditory brainstem response using the dipole localizing Method." Neurosciences. 21. 53-58 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamamura T, et al.: "Origin of far-field N18 of SSEPs in response to median nerve." Neurosciences. 21. 123-129 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 安原昭博、他: "小児における巨大SEP群とSEP無反応群" 臨床脳波. 37. 590-592 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 田 悦、他: "小児の頭部外傷性脳血管障害における誘発電位の変化について" 臨床脳波. 37. 68-73 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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