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Studies on the absorption, metabolism and storage of vitamins K

Research Project

Project/Area Number 06670845
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Occupational and Envirommental Health, Japan

Principal Investigator

SHIRAHARA Akira  Univ. of Occupational and Environmental Health, Japan, Professor, 医学部, 教授 (10081712)

Co-Investigator(Kenkyū-buntansha) MIYAGAWA Takayuki  Univ. of Occupational and Environmental Health, Japan, Lecturer, 医学部, 講師 (90219733)
ARIYOSHI Nobuaki  Univ. of Occupational and Environmental Health, Japan, Assistant Professor, 医学部, 講師 (40184296)
KAJIWARA Yasuhira  Univ. of Occupational and Environmental Health, Japan, Associate Professor, 医学部, 助教授 (00161042)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
KeywordsVitamin K / Aging / Liver / Intestinal flora / PIVKA / Hemorrhagic disease of the newborn / Vitamin K deficiency in infancy / 原発性肝癌 / 腸内細菌叢 / 抗生剤 / NMTT / 新生児
Research Abstract

We studied the absorption, metabolism and storage of K vitamins in order to clarify the human requirement of K vitamins. We also surveyed the present status of neonatal vitamin K prophylaxis in Japan. Main data obtained from this research project were as follows.
1. Neonatal stool contents of K vitamins decreased after the administration of antibiotics. Decrease of vitamin K content was correlated with the changing pattern of intestinal flora.
2. Vitamin K is retained in liver tissue for a relatively long period after the administration of vitamin K delivertives.
3. The vitamin K epoxide reductase activity level of liver disease patients is lower than that of normal control. Decreased activity of this enzyme is observed in patients with not only severe liver disease, but also very mild liver disease.
4. Based on our survey of neonatal vitamin K deficiency, the optimal program of vitamin K prophylaxis for hemorrhagic disease in high-risk newborns still needsto be established.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] 白幡聡: "メレナ" 産科と婦人科. 61. 168-169 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡、有吉宣明: "ビタミンK欠乏症" 臨床病理. 特集97号. 256-259 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "ビタミンK" 日本臨牀. 53. 722-725 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡他: "未熟児・新生児へのビタミンK投与の現状" 日本産婦人科・新生児血液学会雑誌. 5. 67-73 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡、宮川隆之: "ビタミンK補充療法-効果と限界-" 小児科診療. 58. 2091-2098 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 梶原康巨・宮川隆之・白幡聡: "頻回輸血とC型肝炎" 小児内科. 27. 569-574 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡他: "肝炎" Biomedical Perspectives. 4. 245-251 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "ビタミンKの構造と作用機序" Biomedical Perspectives. 5(1). 10-17 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "ビタミンK拮抗物質とPIVKA" Biomedical Perspectives. 5(1). 81-87 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮川隆之: "治療薬としてのビタミンK-最近の課題" 日本小児臨床薬理学会誌. 9(1). 29-33 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "新生児出血性疾患" 周産期医学. 26(10). 1443-1448 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "ビタミンK欠乏症" 小児内科(増刊号). 28. 1065-1068 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "止血・血栓・線溶(分担:ビタミンKとアンタゴニスト)" 中外医学社, 500 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡・有吉宣明: "臨床血栓止血学(分担:ビタミンK欠乏症)" 医歯薬出版, 489 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "最新内科学大系6<肥満症,臨床栄養>(分担:ビタミンK)" 中山書店, 345 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "この薬この副作用(分担:ワルファリンカリウムと止血異常)" 医歯薬出版株式会社, 333 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡聡: "臨床新生児栄養学(分担:ビタミンK欠乏性出血症への対策)" 金原出版株式会社, 442 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shirahata A.et al.: "Present status of neonatal vitamin K prophylaxis in Japan-Nationwide survey-. The Japanese" Journal of Obstetrical, Gynecological & Neonatal Hematology. 5 (3). 67-73 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shirahata A.: "Structure and the mechanism of action of vitamin K." Biomedical Perspectives. 5 (1). 11-17 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shirahata A.: "Vitamin K antagonists and PIVKA." Biomedical Perspectives.5 (1). 81-87 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Miyakawa T.et al.: "Vitamin K as a drug-Current topics-" The Japanese Journal of Developmental Pharmacology and Therapeutics.9 (1). 29-33 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 白幡 聡: "ビタミンKの構造と作用機序" Biomedical Perspectives. 5(1). 10-17 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白幡 聡: "ビタミンK拮抗物質とPIVKA" Biomedical Perspectives. 5(1). 81-87 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮川隆之: "治療薬としてのビタミンK-最近の話題" 日本小児臨床薬理学会誌. 9(1). 29-33 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白幡 聡: "新生児出血性疾患" 周産期医学. 26(10). 1433-1448 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白幡 聡: "ビタミンK欠乏症" 小児内科(増刊号). 28. 1065-1068 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白幡 聡: "この薬のこの副作用(分担)" 医歯薬出版株式会社, 333 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白幡 聡: "臨床新生児栄養学(分担)" 金原出版株式会社, 442 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 白幡 聡 他: "未熟児・新生児へのビタミンK投与の現状" 日本産婦人科・新生児血液学会雑誌. 5. 67-73 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白幡聡・宮川隆之: "ビタミンK補充療法-効果と限界-" 小児科診療. 58. 2091-2098 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 梶原康巨・宮川隆之・白幡聡: "頻回輸血とC型肝炎" 小児内科. 27. 569-574 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白幡 聡 他: "肝炎" Biomedical Perspectives. 4. 245-251 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白幡 聡: "臨床新生児栄養学(分担)ビタミンK欠乏性出血症への対策" 金原出版, 442 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白幡 聡: "最新内科学大系6(肥満症,臨床栄養)(分担:ビタミンK)" 中山書店, 345 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白幡,聡: "メレナ" 産科と婦人科. 61. 168-169 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 白幡,聡: "ビタミンK" 日本臨牀. 53. 722-725 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 白幡,聡.有吉,宣明: "ビタミンK欠乏症" 臨床病理. 特集97号. 256-259 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 白幡,聡: "止血・血栓・線溶(分担:ビタミンKとアンタゴニスト)" 中外医学社, 500 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 白幡,聡.有吉,宣明: "臨床血栓止血学(分担:ビタミンK欠乏症)" 医歯薬出版, 489 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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