| Project/Area Number |
06670848
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
KAGA Makiko Department of Developmental Disorders, National Institute of Director Mental Health, NCNP, 精神保健研究所・精神薄弱部, 部長 (20142250)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UNO Akira Department of Developmental Disorders, National Institute of Head Mental Health,, 神経センター・精神保健研究所・精神薄弱部・治療研究室, 室長 (10270688)
INAGAKI Masumi Department of Developmental Disorders, National Institute of Head Mental Health,, 神経センター・精神保健研究所・精神薄弱部・診断研究室, 室長 (70203198)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
|---|
| Keywords | chronic consciousness disorder / developmental disorders / visual perception / passive event related potential / P300 / mismatch negativity |
|---|
| Research Abstract |
This study vestigated whether mismatch negativity (MMN) of visual evoked potentials could be used to evaluate visual perception in patients with severe chronic consciousness disorder. Subjects were chosen from among 6 patients whose consciousness was severely impaired for more than 3 years. This patient an 11 yearold girl who had been in a vegetative state since two episodes of cerebral infarction caused by hypercholesterolemia. Visual targets were selected by careful clinical observation. They were 1) the faces of Dr.A (her attending physician) and Dr.B (a physician not familiar to her), 2) Dr.A's smiling and serious face, and 3) Dr.A's serious and smiling face. Controls were 5 healthy children and adults. The former visual stimulation in target of each paradigm was presented in 15% of all trials and the latter was presented in 85% of the trials. Passive P300 was elicited in condition 1) as previously reported. New findings were the presence of passive P300 to differences in facial expression of the same person (Dr.A) and that the presence of MMN elicited by all three conditions. Thus MMN of visual ERPs can contribute to determining whether patients in a chronic vegetative state can discriminate certain visual targets.
|
