| Project/Area Number |
06670861
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
DANNO Kiichiro Shiga University of Medical Science Department of Dermatology, Associate Professor, 医学部, 助教授 (00115883)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Hisashi Shiga University of Medical Science Department of Dermatology, Lecturer, 医学部, 講師 (00162868)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Cyclosporine / Mechanism / Skin / Therapy / Ultraviolet / Vitamie D |
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| Research Abstract |
1. Clinical Research on Therapeutic Mechanisms of Psoraren Photochemotherapy (PUVA) Combined With Vitamin D3 Ointment in Psoriasis Vulgaris
A right-left comparative study in psoriasis vulgaris demonstrated that PUVA + tacalcitol ointment (TL) was better than PUVA + steroid ointment (ST) or vehicle (V) alone. Histological and immunohistochemical studies showed that the increased number or degree of epidermal thickness, Ki-67+ cells, infiltrating leukocytes, and cell adhesion molecule expression in pretreated lesion was reduced to a greater extent after PUVA + TL than after PUVA + ST or V.Therapeutic mechanisms of PUVA + TL may be attributed to both antiproliferative and immunomodulatory effects.
2. Basic Research on Therapeutic Mechanisms of Cyclosporin A Combined With Ultraviolet-B-Photocherapy
Cyclosporin A (CyA,5-50 mg/kg/day) or vehicle (V) alone was administered per os to BALB/c mice for 5 days, and mouse ears were exposed to UVB (100-500 mJ/sq cm). UVB radiation inceased the number of 5-bromodeoxyuridine (BrdU)+ cells at 24h after transient suppression. CyA,but not V alone, significantly suppressed UVB-induced increment in BrdU+ cells. Cya+UVB significantly decreased Langerhans cell (LC) coants than each treatment alone. CyA and UVB may cooperate to suppress increased epidermal proliferation and LC counts, both of which are partly responsible for psoriasis.
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