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Basic research for glucose metabolism in inflammatory tissue by positron-labelled glucose analog

Research Project

Project/Area Number 06670899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

YAMADA Susumu  Institute for Development, Aging & Cancer, Department of Nuclear Medicine & Radiology, Tohoku University Assistant Professor, 加齢医学研究所, 講師 (70182532)

Co-Investigator(Kenkyū-buntansha) KUBOTA Kazuo  Institute for Development, Aging & Cancer, Department of Nuclear Medicine & Radi, 加齢医学研究所, 助教授 (40161674)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Keywordsglucose metabolism / FDG / inflammation / autoradiography / tissue distribution
Research Abstract

1.Tissue distribution of ^<18>FDG in turpentine-induced inflammatory tissue was investigated. Maximum uptake of ^<18>FDG was observed 1 hour after the ^8FDG injection and the uptake in chronic phase was higher than that in acute phase.
2.Relations between the inflammatory composition factor and the ^<18>FDG uptake was examined by macro and micro-autoradiography (ARG). On macro-and micro-ARG,the highest grain density due to ^<18>FDG uptake was observed in marginal zone of abscess wall consisting many inflammatory cells of neutrophils and macrophages, epithelial cells of blood vessel and young fibroblasts. Results indicate that increased permeability of capillary blood vessels result in a leakage of fluid including ^<18>FDG into the extra-vascular space and the ^<18>FDG was utilized as energy source. Relations between other factors of vascular permeability and blood glucose and ^<18>FDG uptake were also examined. Double-tracer tissue distribution study, of ^<131>I serum albumin as indicator of vascular permeability and the ^<18>FDG showed that the ^<18>FDG uptake depended on the vascular permeability. In glucose and insulin loaded tissue distribution study, ^<18>FDG uptake in inflammatory tissue in control group was lower than in glucose loaded group and insulin group, thus indicating the complicated influence of blood glucose and insulin on glucose metabolism in inflammtory tissue.
3.In granulocyte-colony-stimulating-factor (G-CSF) loaded tissue distribution study, ^<18>FDG uptakes in inflammatory tissue, spleen and bone were significantly higher than those in control group. This result may reflects the direct function of G-CSF as cytokine.
4.In double-tracer tissue distribution study of ^<67>Ga citrate and ^<18>FDG,both maximum uptakes were also observed on Day 4 after inoculation of turpentine-oil. However, on double-tracer macro-ARG,the highest uptake of ^<67>Ga citrate was observed outside abscess wall and the highest of ^<18>FDG was inside.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Susumu Yamada: "Effect of blood glucose on ^<18>F-FDG uptake in experimental inflammatory tissue." CYRIC Annual Report. 126-127 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Susumu Yamada: "Autoradiographic study of ^<67>Ga-citrate and ^<18>F-FDG uptake in experimental inflammatory tissue." CYRIC Annual Report. 171-173 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Roko Kubota: "Microautoradiographic study for the differentiation of intratumoral macrophages,granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake." Journal of Nuclear Medicine. 35. 104-112 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Susumu Yamada: "High accumulation of fluorine-18-fluorodexyglucose in turpentine-induced inflammatory tissue." Journal of Nuclear Medicine. 36. 1301-1306 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazuo Kubota: "Feasibility of fluorine-18-fluorophenylalanine for tumor imaging compared with carbon-11-methionine." Journal of Nuclear Medicine. 37. 320-325 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Michael J.Reinhardt: "Assessment of cancer recurrence in residual tumors after fractionated radiotherapy:a comparison of fluorodeoxyglucose,L-methionine and thymidine." Journal of Nuclear Medicine. 38. 280-287 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Susumu Yamada, et al.: "Effect of blood glucose on ^<18>F-FDG uptake in experimental inflammatory tissue." CYRIC Annual Report. 126-127 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Susumu Yamada, et al: "Autoradiographic study of ^<67>Ga-citrate and ^<18>F-FDG uptake in experimental inflammatory tissue." CYRIC Annual Report. 171-173 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Roko Kubota, et al: "Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake." Journal of Nuclear Medicine. 35. 104-112 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Susumu Yamada, et al: "High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue." Journal of Nuclear Medicine. 36. 1301-1306 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazuo Kubota, et al.: "Feasibility of fluorine-18-fluorophenylalanine for tumor imaging compared with carbon-11-methionine." Journal of Nuclear Medicine. 37. 320-325 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Michael J.Reinhardt, et al: "Assessment of cancer recurrence in residual tumors after fractionated radiotherapy : a comparison of fluorodeoxyglucose, L-methionine and thymidine." Journal of Nuclear Medicine. 38. 280-287 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Susumu Yamada: "Effect of blood glucose on ^<18>F-FDG uptate in experimental inflammatory tissue." CYRIC Annual Report. 126-127 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Susumu Yamada: "Autoradiographic study of ^<67>Ga-citrate and ^<18>F-FDG uptake in experimental inflammatory tissue." CYRIC Annual Report. 171-173 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Roko Kubota: "Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake." Journal of Nuclear Medicine. 35. 104-112 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Susumu Yamada: "High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue." Journal of Nuclear Medicine. 36. 1301-1306 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazuo Kubota: "Feasibility of fluorine-18-fluorophenylalanine for tumor imaging compared with carbon-11-methionine." Journal of Nuclear Medicine. 37. 320-325 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Michael J. Reinhardt: "Assessment of cancer recurrence in residual tumous after fractionated radiotherapy : a comparison of fluorodeoxyglucose, L-methionine and thymidine." Journal of Nuclear Medicine. 38. 280-287 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Susumu Yamada: "High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue." Journal of Nuclear Medicine. 36. 1301-1306 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Susumu Yamada: "Effect of blood glucose on 18F-FDG uptake in experimental inflammatory tissue." CYRIC Annual Report. 126-127 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Susumu Yamada: "High accumulation fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue." Journal of Nuclear Medicine. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuo Kubota: "Effects of radiotherapy on the cellular uptake of carbon-14 labeled L-methionine in tumor tissue." Nuclear Medicine and Biology. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Roko Kubota: "Methionine uptake by tumor tissue;A microautoradiographic comparison with FDG." Journal of Nuclear Medicine. 1995. (Roko Kubota)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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