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Assessment of the effectiveness of cancer therapy using PET.

Research Project

Project/Area Number 06670914
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNagoya University School of Medicine

Principal Investigator

ISHIGAKI Takeo (1995-1996)  Nagoya University School of Medicine, Department of Radiology, Professor, 医学部, 教授 (60094356)

伊藤 健吾 (1994)  名古屋大学, 医学部, 講師 (70184653)

Co-Investigator(Kenkyū-buntansha) YAMADA Tetsuya  Nagoya University School of Medicine, Department of Radiology, Assistant, 医学部, 助手 (30252240)
FUKATSU Hiroshi  Nagoya University School of Medicine, Department of Radiology, Assistant, 医学部, 助手 (70228865)
IKEDA Mitsuru  Nagoya University School of Medicine, Department of Medical Informatics, Associa, 医学部, 助教授 (50184437)
KATO Takashi  National Institute for Longevity Sciences, Department of Biofunctional Research,, 長寿医療研究センター・生態機能研究部, 室長 (60242864)
ITO Kengo  National Institute for Longevity Sciences, Department of Biofunctional Research, (70184653)
石垣 武男  名古屋大学, 医学部, 教授 (60094356)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
KeywordsPET / FDG / Fluorodeoxyglucose / Cancer / Radiation Therapy / Rectal Cancer / Lung Cancer / Cellularity / 治療効果判定 / 治療効果予測 / VX-2腫瘍 / タリウムTlCl / FIBI / 化学療法
Research Abstract

Morphologiacal imaging strategies such as plain radiography, X-ray CT,MRI and ultrasonography have been used for the evaluation of cancer treatment. The shape and diameter of tumor are compared before and after the treatment. Occasionally, we meet the cases of residual mass without viable tumor cells after the therapy. And there are many cases of early recurrent disease even if we could not identify the residual mass just after the treatment. Morphological approach has limited ability in the assessment of cancer therapy.
FDG-PET has been accepted as a useful diagnostic tool in oncology. We applied FDG-PET study to the assessment of cancer treatment and compared with the morphological methods. Three consecutive FDG-PET studies before, in the middle of and after the radiation therapy were performed in fifteen patients with non-small cell lung carcinomas. FDG accumulation to the tumors were compared in three scans of each patient. Reduction of tumor size measured by plain radiography or CT … More after the treatment was correlated to FDG accumulation in most of the patients. However, there were some patients without agreement between morphological study and FDG-PET.These results suggest that FDG-PET has different information on the number of tumor cells and metabolic activity.
Cellularity of the tumor and partial volume effect were studied, as a basic study of FDG uptake to tumor. Thirty-seven patients with suspected recurrent disease of rectal cancer were studied with FDG-PET.Correlation between the size of tumors and the FDG uptake was studied. FDG accumulation was compared to cellularity observed in histopathological examinations in several subjects. Positive correlation was found between the size and the uptake. This suggests that the size of the tumor should be taken into consideration for accurate estimation of FDG uptake. There was a correlation between cellularity and FDG uptake. When FDG-PET is used for the evaluation of therapy, the accumulation of FDG is considered to be dependent on the number of residual tumor cells.
FDG-PET is able to provide new information, which could not be obtained by conventional morphological diagnostic imaging technique. FDG-PET is aeffective method for the assessment of cancer therapy. Less

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Ito k, Kato T, ohta T, Todolorc H, Yorada T, Ikeda, M Nielinop, Ishigaki T: "Fluorine-18 Fluoro-2-deoxyglucose positron emisslon tonography in recurrent rectal cancer: relation to tumour size and cellutarity." European Journal of Naclear Medicine. 23. 1372-1377 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ito K,Kato T,Ohta T,Tadokoro M,Yamada T,Ikeda M,Nishino M,Ishigaki T,Ito K,Gambhir S.: "Fluorine-18 fluoro-2-deoxyglucose positron emission tomography in recurrent rectal cancer : relation to tumour size and cellularity." European Journal of Nuclear Medicine. vol.23. 1372-1377 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ito K,Kato T,Ohta T,Tadokoro M,Yamada T,Ikeda M,Nishino M,Ishigaki T: "Fluorine-18 fluoro-2-deoxyglucose positron emission tomogtaphy in recurrent rectal concer : relation to tumor size and cellularity." European Journal of Naclear Medicine. 23. 1372-1377 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤健吾: "画像診断の親展開-MRI、PETが可能にした病態把握-悪性腫瘍" 最新医学. 49. 96-102 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 伊藤健吾: "最新核医学-クリニカルPETの課題-腫瘍診断へのPETの応用" 新医療. 1. 38-41 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kato T: "Fluorodeoxyglucose positron emission tomography in pancreatic cancer:an unsolved problem" European Journal of Nuclear Medicine. 22. 32-39 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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