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A development of new radiopharmaceuticals for respiratory diseases

Research Project

Project/Area Number 06670939
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionThe Jikei University School of Medicine

Principal Investigator

KAWAKAMI Kenji  The Jikei University School of Medicine, Department of Radiology, Professor, 医学部, 教授 (10056814)

Co-Investigator(Kenkyū-buntansha) YOSHIZAWA Yukio  The Jikei University School of Medicine, Isotope research center, Lecturer, 医学部, 講師 (30119862)
MAKINO Motoji  The Jikei University School of Medicine, Department of Radiology, Lecturer, 医学部, 講師
MOCHIZUKI Sachio  The Jikei University School of Medicine, Department of Radiology, Professor, 医学部, 教授 (10056533)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsVentilation / ^<99m>Tc-technegas / ^<99m>Tc-Pertechnegas / Lung epithelial permeability / Rat / Biodistribution / Radiochromatography / 換気分布 / ^<99m>TcO_4^-エロゾル / ^<99m>Tc-DTPA / ^<99m>Tc-Technegas / ^<99m>Tc-Pertechnegas / ^<99m>Tc-O4 / 肺内クリアランス
Research Abstract

The aim of this study is to generate different tracers from ^<99m>Tc-technegas by using Technegas generator.
Pertechnegas (P-gas) was formed in the generator in the presence of 97% Ar and 3% oxygen.
The easy extractability of P-gas in the phosphate buffered saline (PBS), the distribution seen in rats after intravenous injection of P-gas and the results of the radiochromatography showed that P-gas behaved like pertechnetate (TcO_4^-).
^<99m>Tc-DTPA gas (D-gas) was also generated in the same condition by technegas generator. D-gas showed same physicochemical sharacteristics to P-gas in vitro experiment.
In vivo study, the clearance half time (T_<1/2>) of inhaled P-gas has shown no significant difference to that of TcO_4^- aerosol.
T_<1/2> of P-gas was considerably faster in comparison with T_<1/2> of DTPA aerosol. However, T_<1/2> of P-gas was more rapid in smokers compared with T_<1/2> in nonsmokers (p<0.01).
T_<1/2> of D-gas was 19.8<plus-minus>4.0 min in normal non-smoker subjects, 12.0<plus-minus>2.8 min in smoker subjects, and 31<plus-minus>11.2 min in idiopathic interstitial pneumonia (IIP)
Further study of the clearance of these tracers in pulmonary diseases is required to assess clinical usefulness.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 川上憲司: "テクネガス装置により作成された^<99m>Tc-DTPA微粒子の評価" 日本医学放射線学会誌. 56. 48-52 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "Pertechnegasの物理化学的性状と吸入後の肺クリアランス" 日本核医学会誌. 32. 563-567 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "テクネガス(Technegas)の生成とその応用" Isotope News. 7. 7-9 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "胸腔内悪性および良性病変に対する^<99m>Tc-MIBIのSPECT像" 日本医学放射線学会誌. 55. 587-592 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "吸入シンチグラフィと肺内病変分布" 呼吸. 14. 42-47 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "呼吸機能検査に用いる新しい放射性医薬品の開発に関する研究" INNERVISION. 10. 74- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "医学生のための放射線医学" 金原出版株式会社, 208 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "特発性間質性肺炎とその周辺疾患" 東京医学社, 488 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenji Kawakami: "Characteristics of Radiophamaceutical Delivered from ^<99m>Tc-DTPA in the technegas Generator." Nippon Acta Radiologica. 56-1. 48-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenji Kawakami: "Physicochemical Characterization and Lung Clearance of Pertechnegas." Japan Journal of Nuclear medicine. 32. 563-567 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上憲司: "テクネガス装置により作成された^<99m>Tc-DTPA微粒子の評価" 日本医学放射線学会誌. 56. 48-52 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川上憲司: "Pertechnegasの物理化学的性状と吸入後の肺クリアランス" 日本核医学会誌. 32. 563-567 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川上憲司: "医学生のための放射線医学" 金原出版株式会社, 208 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川上憲司: "特発性間質性肺炎とその周辺疾患" 東京医学社, 488 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川上憲司: "電気インピーダンス法と二重X線吸収法による身体構成成分解析の対比検討" 臨床病理. 42. 1088-1092 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川上憲司: "肺塞栓症における肺血流シンチグラム所見-ストライプサインの意義21GC02:臨床放射線" 39. 1703-1707 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川上憲司: "内科医に必要な核医学の知識-呼吸器疾患" 診断と治療. 82. 49-54 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川上憲司: "呼吸器疾患診断における核医学的アプローチ" 日本胸部疾患学会誌. 53. S125-S132 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川上憲司: "吸入シンチグラフィと肺内病変分布" 呼吸. 14. 42-47 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川上憲司: "医用画像工学ハンドブック" 篠原出版, (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川上憲司: "症例より学ぶ核医学" 廣川書店, (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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