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Lasting alterations of dopamine uptake sites in animal brain after repeated administration of cocaine.

Research Project

Project/Area Number 06670951
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionTohoku University

Principal Investigator

MATSUOKA Hiroo  Tohoku University School of Medicine, Department of Paychiatry, Lecturer., 医学部, 講師 (00173815)

Co-Investigator(Kenkyū-buntansha) NUMACHI Sumiko (YOSHIDA)  Tohoku University, School of Medicine, Department of Psychiatry, Assistant, 医学部, 助手 (50261532)
SATO Mitsumoto  Tohoku University, School of Medicine, Department of Psychiatry, Professor., 医学部, 教授 (70033321)
沼知 陽太郎  東北大学, 医学部附属病院, 助手 (00261636)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordscocaine / reverse tolerance phenomenon / dopamine transporter / [^<125>I] RTI 55 / radiolabeled receptor assay / vulnerability to psychotic relapse / 逆耐性 / ラット / オートラジオグラフィー
Research Abstract

In animals, a long-term behavioral sensitization (LTBS) to cocaine or releasing amines (reverse tolerance phenomenon) has been confirmed after subchronic administration of these central stimulants. A challenge injection of these stimulants to sensitized animals induces a significantly greater increase in dopamine (DA) release in the striatum and nucleus accumbens, which relates to induction and manifestation of the LTBS and the brain vulnerability to psychotic relapse. Since cocaine acts at a dopamine transporter (DAT), DAT may play an essential role for the cocaine-induced LTBS.The cocaine analogue RTI 55 is one of the most potent ligand for DAT.To determine if subchronic administration of cocaine produces long-lasting alterations in DAT,we examined the regional accumulation of [^<125>I] RTI 55 in the cocaine sensitized rat brain by ex vivo autoradiography and in vitro binding of [^<125>I] RTI 55 to DAT in the striatum of cocaine sensitized rats. Male Sprague Dawley rats received a daily injection of cocaine (20 mg/kg, i.p.) for 21 days. Seven days after the last injection, rats in the steady state received i.p.injection of [^<125>I] RTI 55 for the autoradiographical analysis or were decapitated for the radio-labeled receptor assay. In the cocaine sensitized animals, the accumulation of radioactivity decreased significantly more in the brain regions including frontal cortex, striatum and nucleus accumbens. But [^<125>I] RTI 55 binding to the striatal DAT did not change in neither low or high affinity sites. These results suggest that it is difficult to explain the cocaineinduced LTBS by a change in striatal DAT.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] Matsumoto, H.: "Velnerability to psychotic relapse and prediction of long-term prognosis in schizophrenia : Prospective follow-up study." Japanease Journal of Psychiatry and Neurology. 48 (3). 666 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuoka, H.: "Information processing deficits in schizophrenia-an ERP study." Biological Psychiatry. 35 (9). 672 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 松岡 洋夫: "精神分裂病における側頭葉・海馬体積と事象関連電位." 脳波と筋電図. 23 (2). 203 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sato, M.: "Metamfetamina abuso, dipendenz a e psicosi nel pase del sol levant." Medicina delle tossicadipendenze. 11. 48-51 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Numachi, Y. et al: "Ex vivo autoradiography and radiolabeled receptor assey using [^<125>I]RTI 55 in cocaine sensitized rat brani." Journal of Neurochemistry. 65. S170 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Numachi, Y. et al: "Positron emission tomography (PET) study of the alterations in brain dislribytion of [^<11>C] methamphetamine in methamphetamine sensitized dog." Nuclea Medicine and Biology. 22. 803-808 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 吉田 寿美子: "メタンフェタミン慢性投与に伴うラット断崖回避反応の変化." 日本神経精神薬理学雑誌. 15. 397-403 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 吉田 寿美子 他: "メタンフェタミン逆耐性に伴う脳内変化に対する環境因子の影響." 精神薬療基金研究年報. 25. 208-213 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 松岡 洋夫(分担): "精神科症例集2,精神分裂病II-主に病因・病態の立場" 中山書店, 15 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 松岡 洋夫(分担): "視覚と脳波の臨床(事象関連電位)" 新興医学出版社, 9 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 松岡 洋夫(分担): "てんかん:けいれん準備性と発作発現の神経機構" 学会出版センター, 12 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 松岡 洋夫(分担): "視覚と脳波の臨床(読書てんかん)" 新興医学出版社, 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuoka, H., Ueno, T., Saito, H.and Sato, M.: "Vulnerability to psychotic relapse and prediction of long-term prognosis in schizophrenia : prospective follow-up study." Japanease Journal of Psychiatry and Neurology. 48 (3). 666 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuoka, H., Matsumoto, K., Ueno, T., Saito, H.Iosaka, T.and Sato, M.: "Information processing deficits in schizophrenia-an ERP study" Biological Psychiatry. 35 (9). 672 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sato, M.: "Metamfetamina abuso, dipendenz a epsicosi nel pase del sol levant." Medicina delle tossicodipendenze. 11. 48-51 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Andreasen N.C., Bogerts, B., Sato, M.et al.: "Teaching and learning about schizophrenia. A WPA Educational Program. WPA,1994." WPA. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Numachi, Y.and Sato, M.: "Neural mechanism of stimulant-induced psychosis : secondary brain damage following methamphetamine dependence." The Jounal of Pharmacology. 64 (1). 61 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Numachi, Y., Yoshida, S., Toyota, H., Ito, C.Matsuoka, H.and Sato, M.: "EX vivo autoradiography and radiolabeled receptor assey using [^<125>I] ETI 55 in the cocaine sensitized rat brain." Journal of Neurochemistry. 65. s170 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mizugaki, M., Nakamura, H., Hishinuma, T.Tomioka, Y., Ishiwata, S., Suzuki, H., Ido, T., Iwata, R., Funaki, Y., Itoh, M., Sato, M.Numachi, Y.and Yoshida, S.: "Positoron emission tomography (PET) study of the alterations in brain distribution of [^<11>C] methamphetamine in methamphetamine sensitized dog." Nuclea Medicine and Biology. 22. 803-808 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshida, S., Numachi, Y., Matsuka, H.and Sato, M.: "Changes in cliff avoidance reaction induced by subchronic methamphetamine administration in rats." The Japanease Journal of Psychiatry and Neurology. 48 (3). 684 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshida, S., Numachi, Y., Matsuoka, H.Fuse, Y.and Sato, M.: "Reverse-tolerance in methamphetamine-induced behavioral stereotypy and impairment of cliff avoidance reaction after subchronic methamphetamine administration in rats." Japanease Journal of Psychopharmacology. 15 (in japanease). 397-403 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuoka, H: "Vulnerability to Psychotic relapse and Prediction of long-term prognosis in schizophrenia : prospective follow-up study." Japanease Jounal of psychiatry and Neurology. 48 (3). 666- (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsuoka, H.: "Information processing deficits in schizophrenia-an ERP study." Biological Psychiatry. 35 (9). 672- (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松岡洋夫: "精神分裂病における側頭葉・海馬体積と事象関連電位." 脳波と筋電図. 23 (2). 203- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sato, M.: "Metamfetamina asuso, dipendenz a e psicosi nel pase del sol levant." Medicina delle tossicodipendenze. 11. 48-51 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Numachi, Y.: "EX vivo autoradiography and radiolabeled receptor assey using [^<125>I]RTI 55 in the cocaine sensitized rat brain." Journal of Neurochemistry. 65. s170- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Numachi, Y. et al.: "Positoron emission tomography (PET) study of the alterations in brain distribution of [^<11>C] methamphetamine in methamphetamine sensitized dog." Nuclea Medicine and Biology. 22. 803-808

    • Related Report
      1995 Annual Research Report
  • [Publications] 吉田寿美子: "メタンフェタミン慢性投与に伴うラット断崖回避反応の変化." 日本神経精神薬理学雑誌. 15. 397-403

    • Related Report
      1995 Annual Research Report
  • [Publications] 吉田寿美子他: "メタンフェタミン逆耐性に伴う脳内変化に対する環境因子の影響." 精神薬療基金研究年報. 25. 208-213 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松岡洋夫(分担): "精神科症例集2,精神分裂病II-主に病因・病態の立場" 中山書店, 15 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松岡洋夫(分担): "視覚と脳波の臨床" 新興医学出版社, 9 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松岡洋夫(分担): "てんかん:けいれん準備性と発作発現の神経機構" 学会出版センター, 12 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松岡洋夫(分担): "視覚と脳波の臨床" 新興医学出版社, 4 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 吉田寿美子(分担): "薬物依存と脳障害" 学会出版センター, ((印刷中))

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsuoka,H.: "Information processing deficits in schizophrenia:an ERP study." Biol.Psychiatry. 35. 615 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Saito,H.: "Information processing deficits in mood disorder:an ERP study." Biol.Psychiatry. 35. 615 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ueno,T.: "Information processing deficits in temporal lobe epilepsy:an ERP study." Biol.Psychiatry. 35. 615 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsuoka,H.: "Clinical approach to psychotic symptoms in temporal lobe epilepsy:vulnerability hypothesis of“Epileptic Psychosis"." Jpn.J.Psychiatry Neurol.48. 213-216 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sato,M.: "Metamfetamina abuso,dipendenza e psicosi nel paese del sol levante." Medicina delle tossicodipendenze. 2. 48-51 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤光源(共著): "脳機能の解明-分子から病態まで-" 創風社, 286 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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