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PHYSIOLOGICAL EFFECTS OF CHOLESTERYL ESTER TRANSFER PROTEIN ON ATHEROSCLEROSIS

Research Project

Project/Area Number 06671052
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionTEIKYO UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

KINOSHITA Makoto  TEIKYO UNIVERSITY SCHOOL OF MEDICINE ASSOCIATE PROFESSOR, 医学部, 講師 (70186295)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsCHOLESTERYL ESTER TRANSFER PROTEIN / ATHEROSCLEROSIS / REVERSE CHOLESTEROL TRANSPORT / HIGH DENSITY LIPOPROTEIN / LOW DENSITY LIPOPROTEIN / ALCOHOL / SMOKING / GENDER / HDL / LDL / アポ蛋白 / リポ蛋白 / 飲酒
Research Abstract

Cholestryl ester transfer protein (CETP) is one of factors that regulates plasma levels of HDL-choesterol. To idntify the factors that may regulate CETP activity, and to determine to what extent CETP is correlated with pysiologic concentrations of lipoprotein, we performed an epidemilogic study in 586 healty volunteers (317 males and 269 females, mean age 52.2<plus-minus>10.9 yrs) . CETP activity in these subjects was 192.96<plus-minus>48.73 (mean<plus-minus>SD) nmol/ml/hr and distributed to a wide range (60 to 450 nmol/ml/hr) . Using multiple regression analysis, we found significant positive correlations between CETP activity and LDL-cholesterol (p<0.03) , apolipoprotein (apo) E (p<0.005) and LCAT activity (p<0.001) . CERP activities showed significant negative correlation with apo A-1 (p<0.03) . However , CETP activity showed no significant correlation either with HDL cholesterol or with apo B.One-way layout analysis of variance showed that alcohol drinking and cigarette smoking significantly reducd CETP activity, but there was no significat association between CETP activity and body mass index. Although CETP activities were significantly higher in females than in males (p<0.001) , multiple regression analysis showed no correlation between CETP activity and age in either the males or the females. Our results suggest that CETP activity regulates the concentration of apo A-1 and LDL-cholesterol, and that such activity may be influenced by gender, alcohol consumption and cigaratte sm

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] M.Kinoshita,et al.: "CETP is a determinant of serum LDL-cholesterol" Atherosclerosis. 120. 75-82 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sato,et al.: "Enzyme-linked immuns sorbant assay for cholesteryl" Clinica Climica Acta. 240. 1-9 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Teramoto,et al.: "Binding of vitamine D to low-density-lipoprotein" Biochem Biohys Res Commun. 215. 199-204 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Nagayoshi,et al.: "Defect in assembly process of very-low density" J.Biochem.117. 787-793 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Watanabe,et al.: "Prostaglandin F2α enhances tyrosine phosphorylation" J.Biol.Chem.269. 17619-17625 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ohama,et al.: "Effect of starving and refeeding on lipid" J.Biochem.115. 190-193 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.HASHIMOTO et al.: "Ca^<2+> entry pathway activated by the tumor promoter thapsigargin in human platelets" Biochim.Biophy.Acta. 1220. 37-41 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.TERAMOTO et al.: "Effect of chyclonicron remnants on apolipopretein E synthesis in HepG2 cells" Metabolism.43. 44-50 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.OHHAMA et al.: "Effect of starving and refeeding on lipid metabolism in suncus" J.Biochem.115. 190-193 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.NAGAYOSHI et al.: "Deficiency of acyl CoA cholesterol acyl transferase activity in suncus liver" J.Biochem.115. 858-861 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.WATANABE et al.: "Prostaglandin F2_<alpha> enhaces tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca^<2+>-dependent intracellular pathway in NIH-3T3 cells" J.Biochem.269. 17619-17625 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.MATSUO et al.: "A variant form of hypobetalipoproteinaemia associated with ataxia, hearing loss and retinitis pigmentosa" Developmental Medicine & Child Neurology. 36. 115-1020 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.NAGAYOSHI et al.: "Defect in assembly process of very-low density lipoprotein in suncus liver : an animal model of fatty liver" J.Biochem.117. 787-793 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.NAGAYOSHI et al.: "Role of acyl coenzyme A cholestorol acyltransferase in intrahepatic processing of apo B-lipoprotein in suncus" J.Biochem.118. 259-264 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.SATO et al.: "Enzyme-liked immunosorbant assay for cholesteryl ester transfer protein in human serum." Clinica Chimica Acta. 240. 1-9 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.TERAMOTO et al.: "Binding of vitamine D to low-density-lipoprotein (LDL) and LDL receptor-mediated pathway into cells." Biochem.Biophys.Res.Commun.215. 199-204 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.KINOSHITA et al.: "CETP is a determinant of seum LDL-cholesterol but not HDL-cholesterol in healthy Japanese" Atherosclerosis. 120. 75-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M. Kinoshita et. al: "CETP is a determinant of serum LDL-cholesterol...." Atherosclerosis. 120. 75-82 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Sato et al: "Enzyme-linked immunosorbant assay for cholesteryl...." Clinica Chimica Acta. 240. 1-9 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Teramoto et al: "Binding of vitamine D to low-density-lipoprotein...." Biochem. Biophys. Res. Commun.215. 199-204 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A. Nagayoshi et al: "Detect in assembly process of very-low density...." J. Biochem.117. 787-793 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A. Nagayoshi et al.: "Role of acyl coenzyme A cholesterol...." J. Biochem.118. 259-264 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 木下誠: "コレステロールエステル転送蛋白の動脈硬化症発症に与える影響" 臨床成人病. 25. 1321-1322 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Nagayoshi et al: "Deficiency of acyl CoA cholesterol acyl transterase activity in suncus liver" J.Biochem. 115. 858-861 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Watanabe et al.: "Prostaglandin F2x enhances tgrosire phospho rylation…" J.Biol Chem. 269. 17619-17625 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Ohama et al.: "Effect of starving and refeeding on lipid metabolism in suncus." J.Biochem. 115. 190-193 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Teramoto et al: "Effect of chylomicron remnants on apolipo prote in E…" Metabolism. 43. 44-50 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 木下 誠: "脂質、リポ蛋白代謝と動脈硬化" current therapy. 12. 13-16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 木下 誠: "高脂血症治療の基本" medicina. 31. 1509-1511 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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