| Project/Area Number |
06671159
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
YUMURA Wako Department of Medicine, Kidney Center and Institute of Endocrinology, Tokyo Women's Medical College, Associate professor, 医学部, 助教授 (50075438)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Naoki Tokyo Metropolitan Institute of Gerontology, Department of Molecular Pathology,, 分子病理, 部長 (00115940)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | SMP30 / renal diseases / recombinant protein / モノクロナール抗体 / 腎尿細管 / 腎疾患 / モノクローナル抗体 |
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| Research Abstract |
We prepared three monoclonal antibodies against recombinant human SMP30 protein. These monoclonal antibodies specifically reacted with SMP30 in tissues. Next by using monoclonal antibodies, we established a sensitive assay to measure serum levels of human SMP30. In normal serum the amount of SMP30 5 pg/ml. We now are analyzing the relationship between serum SMP30 level and diseases. This assay system has a possibility to be important parameter for clinical study on kidney and liver diseases.
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