| Project/Area Number |
06671183
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
YAMAMORI Hideo Chiba university, Medicins, Lecturer, 医学部, 講師 (00166836)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Nobuo Chiba university, Medicine, Assistant professor, 医学部, 助教授 (90111426)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Pancreas cancer / Serum factors / K-ras / Oncogene / Mutation / K‐ras / 突然変異誘発因子 / 形質変異 |
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| Research Abstract |
Serum factors which enhance induction of K-ras oncogene mutation were searched for in sera from pancreas cancer patients. Sera were fractionated by chromatography and tested for the activity to enhance protease-inducibility in lymphocytes from healthy donors. Fractions with the enhancement were examined with respect to the activity to enhance induction of phenotypic mutation in cultured human cells, following the examination of the activity to enhance induction of base substitution mutations of K-ras codon 12 in human cells. Sera from one patient were fornd to have the enhancement activity on phenotypic and genetic mutation. Results may indicate that high incidence of K-ras codon 12 mutations in pancreas cancer is partly due to enhancement of the mutation by the serum factors found here.
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