| Project/Area Number |
06671195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KANEKO Hirochi Hamamatsu Univ. School of Medicine Secoud depar of Surgery, 医学部附属病院, 助手 (10204562)
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| Co-Investigator(Kenkyū-buntansha) |
蜂谷 貴 浜松医科大学, 医学部, 助手 (70238020)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | acute arterial occlusion / MNMS / tissue factor / ischemia-reperfusion |
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| Research Abstract |
Activation of tissue factor in MNMS due to acute arterial occlusion and its influence to general organs
(1) Change of blood tissue factor level before and after aortic clamping in aortic aneurysm surgery
We investigated the change of blood tissue factor level before and after aortic clamping in 6 cases of aortic aneurysm surgery. Blood tissue factor level of the first operative day was a little higher than that of pre-operative day, and then decreased on 3rd and 5th operative day. On 7th operative day, blood tissue factor level again increased and decreased on 14th operative day.
(2) MNMS and remote organ failure due to the broad type of acute arterial occlusion
In acute arterial occlusion, the broad type in which ischemic change reached beyond the knee often compricates MNMS and has poor prognosis. Twenty-one cases of the broad type of acute arterial occlusion were studied. Five of seven cases who were alive complicated MNMS,but most of them had only renal failure. Eleven of fourteen cases who were dead complicated MNMS,and most of them had multiple organ failure.
(3) Intestinal ischemia-reperfusion and pulmonary injury
We investigated the pulmonary injury as a remote organ failure after intestinal ischemia-reperfusion using rat intestinal ischemia-reperfusion model. After 30-minute ischemia by clamping superior mesenteric artery, the change of pulmonary weight was measeured. After ischemia-reperfusion, pulmonary weight/body weight increased significantly. It is suggested that pulmonary edema may occur after intestinal ischemia-reperfusion.
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