| Project/Area Number |
06671206
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
NAOMOTO Yoshio Okayama University, Medical School, First Department of Surgery, Instructor, 医学部・附属病院, 助手 (00237190)
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| Co-Investigator(Kenkyū-buntansha) |
ORITA Kunzo Okayama University, Medical School, First Department of Surgery, Professor, 医学部, 教授 (20033053)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | tumor necrosis factor / macrophage colony stimulating factor / rejection / organ transplantation / inflammation / sepsis / skin graft / macroploge / CSF / cytohinl / macroplagl colony stimulating bactor / 移植臓器拒絶反応 |
|---|
| Research Abstract |
Macrophage-colony stimulating factor (M-CSF) was discovered as a factor stimulating production, muturation and function of monocytes. Subsequent investigations have revealed that M-CSF has a variety of functions such as stimulation of neutrophil and platelet production, antifungal activity, tumoricidal effect, induction of villous cell differentiation, decrease in cholesterol, suppression of arteriosclerosis and differentiation and maturation of osteoclasts. However, many points of the mechanism of M-CSF actions remain unclear. Our investigations have demonstrated that M-CSF administration markedly inhibited cytokine production in response to stimulation with lipopolysaccharide (LPS) in mice presensitized by BCG.
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