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Study of Endoscopy-guided LASER Therapy for Intraductal Minimal Lesions of the Breast

Research Project

Project/Area Number 06671217
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionSapporo Medical University, School of Medicine

Principal Investigator

OKAZAKI Akira  Sapporo Medical University, Department of Surgery, Instructor, 医学部, 助手 (50213921)

Co-Investigator(Kenkyū-buntansha) NARIMATSU Eimei  Sapporo Medical University, Department of Surgery, Associate Professor, 医学部, 助教授 (80045343)
HIRATA Koichi  Sapporo Medical University, Department of Surgery, Professor, 医学部, 教授 (50136959)
SATO Takashi  Sapporo Medical University, Department of Surgery, Assistant Professor, 医学部, 講師 (50205928)
OKAZAKI Minoru  Sapporo Medical University, Department of Surgery, Assistant Professor, 医学部, 講師 (30160667)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
KeywordsNipple Discharge / Nonpalpable Breast Cancer / Fiberoptic Ductoscopy Of The Breast / Intraductal Papilloma / LASER Therapy / 乳頭内乳頭腫
Research Abstract

Intraductal papilloma (papilloma) is an main cause of nipple discharge with no palpable mass. The method of endoscopy-guided LASER therapy which was one of non-surgical treatments for papilloma, was studied as well as the possibility of its clinical use. Most of papilloma grew in the lactiferous duct near the nipple and the spreading size was less than 2.0cm. Furthermore, many papilloma showed a filling defect on ductogram and a hemisphere nodule on endoscopic examination. Indication of LASER therapy was as follows ; 1) Solitary filling defect or interruption by filling defect on ductogram near the nipple, 2) Hemisphere nodule on fiberoptic ductoscopy, 3) Results of tube curette cytology is benign. After the informed consent of the LASER therapy, it was performed. The equipment of the LASER therapy was as follows : The diameter of endoscope was 0.65mm or 0.75mm and LASER fiber (outer diameter was 0.20mm) was introduced through the air channnel of the endoscope. Nd-YAG-LASER was used in this study. Papilloma was completely disappeared in four of the six cases. Stenotic changes occurred in two cases and microdochectomy was performed in those patients. The actual energy of 105-928. J.was necessary to treat papilloma. Although there are problems of long treatment time and stenotic change on the ductal surface, this therapy is a valuable method to treat papilloma which could not be cured with non surgical treatment.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] 岡崎,亮他.: "乳管内視鏡の実践" 臨床外科. 49. 33-40 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A. et al.: "Significance of fiberoptic ductoscopy of the breast in the diagnosis for nipple discharge." Int. J. Oncol.5. 391 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, M., Okazaki, A. et al.: "Cytological diagnosis for non-palpable breast cancer:In nipple discharge cases with no palpable mass." Int. J. Oncol.5. 392 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎,亮他.: "無腫瘤性乳癌の内視鏡形態:組織所見との対比" Mamma(第1回日本乳癌学会特集号). 76-77 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎,亮他.: "乳管内良性腫瘍に対する乳管内視鏡下LASER照射" 治療. 76. 187-189 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎稔,岡崎亮他.: "画像診断のポイント:乳管内視鏡のポイントI." Mamma. 19. 18-19 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎亮他.: "画像診断のポイント:乳管内視鏡のポイントII." Mamma. 20. 9-11 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎亮他.: "乳管内微小病変の進展形態からみた乳管内視鏡と乳管造影の診断的意義" 乳癌の臨床. 10. 282-283 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎亮他.: "乳管内視鏡所見からみた内視鏡下微小検体採取法の診断的意義" 乳癌の臨床. 10. 676-677 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎亮他.: "乳管造影" 臨床検査. 10. 1168-1169 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎亮他.: "乳頭異常分泌を主徴とするTo乳癌の画像診断" 臨床画像. 11. 92-98 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎亮他.: "乳管内視鏡の現況と問題点" Breast Cancer Today. 12. 2-8 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎,亮他.: "乳腺甲状腺外科,Panel Discussion 3 非触知乳癌を診断する,バセドウ病を考える" 株式会社インターメルク, 41-50 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎稔,岡崎亮他.: "乳房温存療法のすべて" Medical View社, 62-67 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Significance of fiberoptic ductoscopy of the breast in the diagnosis for nipple discharge." Int.J.Oncol. 5. 391 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, M., et al.: "Cytological diagnosis for non-palpable breast cancer : In nipplle discharge cases witth no palpable mass." Int.J.Oncol. 5. 392 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuukan naishikyou no jissen" Rinsho Geka. 49 (In Japanese). 33-40 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuukannai ryousei shuyou ni taisuru nyuukan nai LASER shousha" J.Therap. 76 (in japanese). 187-189 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuukannai bishou byouhen no shintenkeiai kara mita nyuukan naishikyou to nyuukan zouei no shindanteki igi" Jap.J.Breast Cancer. 10 (in japanese). 282-283 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuukan naishikyou shokenn kara mita naishikyouka bishou kentai saishuou no shindanteki igi" Jap.J.Breast Cancer. 10 (in japanese). 676-677 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuukan zouei" Rinshoukensa. 10 (in japanese). 1168-1169 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuuton ijyou bunpitsu wo shuchou to suru to nyuugan no gazou shindan" Clinical Imagiology. 11 (in japanese). 92-98 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Hi-shokuchi nyuugan wo shindan suru, Basedow byou wo kangaeru" Intermerk. (in japanese). 41-50 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okazaki, A., et al.: "Nyuubouonzonryouhou no subete" Medical View. (in japanese). 62-67 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡崎 亮他.: "乳管内視鏡の実践" 臨床外科. 49. 33-40 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okazaki,A,et al.: "Significance of fiberopic ductoscopy of the breast in the diagnosis for nipple discharge." Int.J.Oncol.5. 391 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okazaki,M.,Okazaki,A.et al.: "Cytological diagnosis for non-palpable breast cancer:In nipple discharge cases with no palpable mass." Int.J.Oncol.5. 392 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "無腫瘤性乳癌の内視鏡形態:組織所見との対比" Mamma(第1回日本乳癌学会特集号). 76-77 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳管内良性腫瘍に対する乳管内視鏡下LASER照射" 治療. 76. 187-189 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 稔,岡崎 亮他.: "画像診断のポイント:乳管内視鏡のポイントI." Mamma. 19. 18-19 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "画像診断のポイント:乳管内視鏡のポイントII." Mamma. 20. 9-11 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳管内微小病変の進展形態からみた乳管内視鏡と乳管造影の診断的意義" 乳癌の臨床. 10. 282-283 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳管内視鏡所見からみた内視鏡下微小検体採取法の診断的意義" 乳癌の臨床. 10. 676-677 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳管造影" 臨床検査. 10. 1168-1169 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳頭異常分泌を主徴とするTo乳癌の画像診断" 臨床画像. 11. 92-98 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳管内視鏡の現況と問題点" Breast Cancer Today. 12. 2-8 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳腺甲状腺外科,Panel Discussion 3 非触知乳癌を診断する,バセドウ病を考える" 株式会社インターメルク, 41-50 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 稔,岡崎 亮他.: "乳房温存療法のすべて" Medical View社, 62-67 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡崎 亮他。: "乳管内視鏡の実践" 臨床外科. 49. 33-40 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Okazaki,A.et al.: "Significance of fiberoptic ductoscopy of the breast in the diagnosis for nipple discharge." Int.J.Oncol.5. 391 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Okazaki,M.,Okazaki,A.et al.: "Cytological diagnosis for non-palpable breast cancer : In niple discharge cases with no palpable mass." Int.J.Oncol.5. 392 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎 亮他.: "無腫瘤性乳癌の内視鏡形態:組織所見との対比" Mamma (第1回日本乳癌学会特集号). 76-77 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳管内良性腫瘍に対する乳管内視鏡下LASER照射" 治療. 76. 187-189 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎 稔,岡崎 亮他.: "画像診断のポイント:乳管内視鏡のポイントI." Mamma. 20. 18-19 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎 亮他.: "画像診断のポイント:乳管内視鏡のポイントII." Mamma. 19. 9-11 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎 亮他.: "乳腺甲状腺外科、Panel Discussion 3 非触知乳癌を診断する、バセドウ病を考える" 株式会社インターメルク, 41-50 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎 稔,岡崎亮他.: "乳房温存療法のすべて" Medical View社, 62-67 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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