| Project/Area Number |
06671222
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Wakayama Medical School |
|---|
Principal Investigator |
NAGAI Yugo Wakayama Medical School, Second Department of Surgery, assistant professor, 医学部, 講師 (00172495)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TUBAKIHARA Hideaki Wakayama Medical School, Second Department of Surgery, assistant staff, 医学部, 助手 (20244741)
TANIMURA Hiroshi Wakayama Medical School, Second Department of Surgery, professor, 医学部, 教授 (10026990)
谷口 勝俊 和歌山県立医科大学, 医学部, 助教授 (90106568)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | w / o / w emulsion / microwave irradiation / polyhematoporphyrin ether / ester |
|---|
| Research Abstract |
In VX2 tumor model of Japanese white rabitts, fundamental investigation on the antitumor effects of microwave irradiation with w/o/w poly-hematoporphyrin ether/ester (PHE) emulsion were carried out.
The intratumoral concentration of PHE at 6 hours after local injection of w/o/w PHE emulsion (in volving PHE 0.5mg/kg) was 10.4<plus-minus>2.4mug/g, and it was almost equal to the concentration after intravenous administration of PHE (2mg/kg). On the other hand, serum concentration of PHE after local injection of w/o/w PHE emulsion was under limit of measuremen
The reduction ratio of the tumor by microwave irradiation after administration of PHE was observed 89.8<plus-minus>12.1% in local injection of w/o/w PHE emulsion and 77.4<plus-minus>20.7% in intravenous administration of PHE,respectively without hyperthermic effect caused by microwave itself. Antitumor effect was not recognized in microwave irradiation al
In conclusion, local injection of w/o/w PHE emulsion may be beneficial as an administration route of PHE and microwave irradiation after PHE administration has possibility for a new treatment of superficial malignant tumors.
|
