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UPPER ESOPHAGEAL SPHINCTER AND RECURRENT LARYNGEALPALSY AFTER ESOPHAGECTOMYFORTHORACIC ESOPHAGEAL CANCER

Research Project

Project/Area Number 06671300
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionOSAKA CITY UNIVERSITY

Principal Investigator

HIGASHINO Masayuki  OSAKA CITY UNIVERSITY MEDICAL SCHOOL,2ND DEPT.OF SURGERY,ASSO.PROFESSOR, 医学部, 助教授 (50137220)

Co-Investigator(Kenkyū-buntansha) OSUGI Harushi  OSAKA CITY UNIVERSITY MEDICAL SCHOOL 2ND DEPT.OF SURGERY,SENIOR LECTURER, 医学部, 講師 (30168926)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥200,000 (Direct Cost: ¥200,000)
KeywordsUpper esophageal sphincter / Recurrent laryngeal palsey / Esophageal cancer / Manometry / 反回神経 / 内圧測定
Research Abstract

The upper esophageal sphincter prevents reflux into the pharynx. If it function improperly, aspiration pneumonia can result. We studied the functioning of the sphincter in unaanesthetized dogs after denervation under anesthesia of the recurrent laryngeal nerves. the pressure of the sphincter at rest was measured by manometry with a transduoer that measured pressurre around the tip of a catheter. Then the pressurre in response to inflation of a balloon to the diameter of 1.5,2.0 and 2.5cm and at 5 and 10cm aboral to the sphincter was measured. Next, the pressure during perfusion of 0.1 NHCl or NaOH 10cm aboral to the sphincter was measured. These studies were done first in 10 dogs that had undergone only gastrostomy for measurements (controls). Measurements were repeated after the left recurrent laryngeal nerve in the control was cut (L group), after the right recurrent laryngeal nerve in the L group was cut (B group), and after transsection of the esophagus 7cm aboral to the sphincter in the B group (Tgroup). The differences in the pressure at rest were not significant. In each group, balloon inflation to any diameter tested and at either position made the pressure rise above that at rest. This pressure in the L,B,and T groups, however, was significantly lower than in the controls. When the balloon was inflated to 2.5cm when it was 10cm aboral to the sphincter, the pressure in the T group was significantly lower than in the Bgroup. When HCl or NaOH were perfused, the pressure increased gradually in the controls, but not in the other groups. In conclusion, although recurrent laryngeal nerves did not affect the function of the sphincter at rest, they were the afferent routes of the contration by the sphincter as a reflex following distension or chemical stimulation of the esophagus. The intramural nerve network of the cervical esophagus may be another reflex route of contraction of the upper esophageal sphincter.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 東野正幸: "Results of surgical treatment for esophageal cacer:extended lymphadenectomy" COLLEGIUM INTERNATIONALE CHIRURGIAE DIGESTIVAE. 49-53 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大杉治司: "嚥下機能からみた食道癌の治療" 外科. 56. 374-380 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 福長洋介: "上部食道昇圧帯機能における反回神経および食道神経叢の関与に関する実験的研究" 日本外科学会雑誌. 95. 643-654 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] MASAYUKI HIGASHINO: "Results of surgical treatment for esophageal cacer : extended lymphadenectomy" COLLEGIUM INTERNATIONALE CHIRURGIAE DIGESTIVAE. 49-53 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] YOSUKE FUKUNAGA: "FUNCTION OF THE UPPER ESOPHAGEAL SHINCTOR AFTER DENERVATION OF RECURRENT LARYNGEAL AND INTRAMURAL NERVES OF THE CERVICAL ESOPHAGUS" JAPAN JOURNAL OF SURGERY. 95. 643-654 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 東野正幸: "Results of surgical treatment for esophageal cacer:extended lymphadenectomy" COLLEGIUM INTERNATIONALE CHIRURGIAE DIGESTIVAE. 49-53 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大杉治司: "嚥下機能からみた食道癌の治療" 外科. 56. 378-380 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 福長洋介: "上部食道昇圧帯機能における反回神経および食道神経叢の関与に関する実験的研究" 日本外科学会雑誌. 95. 643-654 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 東野正幸: "胸部食道癌の術後再建経路別にみた術式の評価" 日本胸部外科学会雑誌. 40. 49-51 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 徳原太豪: "食道癌切除後における上部食道括約筋機能に関する研究" 日本外科学会雑誌. 93. 578-588 (1992)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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