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Mechanism of immune suppression by allogeneic blood transfusion in patients with gastrointestinal cancer.

Research Project

Project/Area Number 06671303
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionSaitama Medical School

Principal Investigator

TOHYAMA Hiroshi  Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (00008278)

Co-Investigator(Kenkyū-buntansha) SHISHIKURA Yuko  Saitama Medical School, Faculty of Medicine, Assistant, 医学部, 助手 (80181105)
MURATA Nobuo  Saitama Medical School, Faculty of Medicine, Ass, Prof., 医学部, 助教授 (10200297)
MAEDA Hiroo  Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (30134597)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Keywordsallogeneic blood transfusion / Gastrointestinal cancer / Immune suppression / Survival rate
Research Abstract

Whether allogeneic blood transfusion gives rise to adverse effect on survival or postoperational infection in patients who received allogeneic blood as compared with those who did not received is controversial. We studied retrospetively survival rate in patients who underwent radical operation for gastrointestinal cancer : 18 allogeneic blood, 33 autologous blood, and 70 no blood transfusion (66 gastric cancer, 29 colon cancer, and 26 rectal cancer), a total of 121 cancer patients were analyzed. We compared 3-year survival rate of the three patient groups ; 86.3% in autologous transfusion group was comparable with 88.1% of no transfusion group but higher, although not significantly, than 76.6% in allogeneic transfusion group. We also analyzed the change of immunological markers, natural killer cell activities and lymphocyte subsets in 8 patients undergoing radical operation. However, we could not find any significant differences among before nad after operation, and among the groups of allogeneic, autologous, and no transfusion. In conclusion, the effects of blood transfusion on survival and immunological markers of the patients with cancer were not demonstrated. A large-scale multi-center study is warranted.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 遠山 博: "自己血輸血の現状そして展望" 骨・関節・靱帯. 7. 741-748 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 遠山 博: "血漿分画製剤-現状と問題点" Biomedical Perspectives. 3. 23-31 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 前田平生: "エリスロポエチンと自己血輸血" Modern Physician. 14. 255-257 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 前田平生: "整形外科領域における自己血輸血施行患者に対するエポエチンベータの臨床評価-皮下投与における第III相試験" 薬学と新薬. 32. 137-157 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤野幸夫: "術前貯血式自己血輸血を行った消化器癌患者の予後と創感染率について" 自己血輸血. 8. 132-136 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Tohyama: "Significances, present situations and prospects of autologous transfusion" Hone-Kansetu-Jintai. 7(7). 741-748 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Tohyama: "Plasma protein fractions-the present states and medical problems" Medical Perspectives. 3(3). 23-31 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Maeda, et al: "Evaluation of epoetinbeta in patients undergoing autologous blood donation for orthopedic surgery-early phase II study of subcutaneous route" Igaku-to-Yakugaku. 33(1). 163-178 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Maeda, et al: "Evaluation of epoetinbeta in patients undergoing autologous blood donation for orthopedic surgery-late phase II study of subcutaneous route" Yakugaku-to-Shinyaku. 32(1). 119-135 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Maeda, et al: "Evaluation of epoetinbeta in patients undergoing autologous blood donation for orthopedic surgery-phase III study of subcutaneous route" Yakugaku-to-Shinyaku. 32(1). 137-157 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Maeda, et al: "Autologous blood transfusion and Erythropoietin therapy" Surgery Frontier. 2(3). 37-41 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Fujino, et al: "The prognosis and wound infection rate of cancer patients who underwent radical operation and received ABT" J.Jap.Soc.Autologous Blood Transfusion. 8(2). 132-136 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤野幸夫: "術前貯血式自己血輸血を行った消化器癌患者の予後と創感染率" 自己血輸血. 8. 132-136 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 前田平生: "自己血輸血とエリスロポエチン療法" Surgery Frontier. 2. 37-41 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 遠山 博: "輸血の歴史と同種血輸血の副作用・合併症" 造血因子. 5. 122-130 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 遠山 博: "自己血輸血の現状そして展望" 骨・関節・靱帯. 7. 741-748 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 前田平生: "エリスロポエチンと自己血輸血" Modern Physician. 14. 255-257 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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