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Inhibitory effects of an antiandrogen agent on experimental esophageal carcinoma in rats

Research Project

Project/Area Number 06671312
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTokai University

Principal Investigator

KONDOH Yasumasa  Tokai University School of Medicine, Department of Surgery Assistant Professor, 医学部, 講師 (00130063)

Co-Investigator(Kenkyū-buntansha) OGOSHI Kyoji  Tokai University School of Medicine, Department of Surgery Associate Professor, 医学部, 助教授 (30112775)
MAKUUCHI Hiroyasu  Tokai University School of Medicine, Department of Surgery Associate Professor, 医学部, 助教授 (80095645)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Keywordsandrogen / Casodex / Esophageal carcinoma / AMN / experimental cancer / casodex
Research Abstract

The incidence of esophageal carcinoma (EC) in men are higher than those in women and the androgen receptor has been detected in human skin cytosol. The purpose of this study is to investigate an inhibitory effect of Casodex on EC in castrated rats (CR) and noncastrated rats (NR).
The weight of the ventral prostate gland after administration of 'Casodex' mixed into daily solid meal for 10 weeks was measured. The weight of the ventral prostate gland in group of 'Casodex' 25 mg/kg (n=5,132+-30 mg) was significantly lower than that in control group (n=5,713+-133 mg) (p<0.001).
The incidence of oesophageal cancer in rats given 'Casodex' for 10 weeks after administration of AMN for 10 weeks was examined histpathologically. The incidence of oesophageal cancer in noncastrated rats administered 'Casodex' as a dose of 25 mg/kg daily (n=7,71.4%) was not lower than that in noncastrated control group (n=9,77.7%). The incidence of oesophageal cancer in castrated rats administered 'Casodex' as a dose of 25 mg/kg daily (n=8,25.0%) was lower than that in castrated control group (n=11,45.4%). We considered that 'Casodex' as a dose of 25 mg/kg has an inhibitory effect on experimental oesophageal cancer in castrated rats.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] KONDOH Y: "Inliltory effecd of flutawide on experiwevtal ocsopbgeol caucer induced by N-Amyl-N-methylui trosomive (AMN) in vats" xxlx world cougress of the international collese of surgeous. 76 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 近藤泰理: "非ステロイド性抗アンドロゲン剤CasodexのAMN(N-Amyl-N-methyl-uitrosamine)ラット実験食道癌における発癌抑制効果について" 日本癌学会総会記事. 第54回. 73 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 近藤泰理: "抗アンドロゲン剤CasodexのAMN(N-Amyl-N-methyl-uitrosamine)ラット実験食道癌における発癌抑制効果" 日本癌学会総会記事. 第55回. 441 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yasumasa Kondoh, Akemi Kamijou, Makiko Tanak, Kyoji Ogoshi, Hiroyasu Makuuchi, Tomoo Tajima, Toshio Mitomi: "Inhibitory effects of Casodex, an antiandrogen agent, on experimental esophageal carcinoma induced by AMN (N-Amyl-N-methylnitrosamine) in rats" Japanese Journal of Cancer Research, Proceedings of the Japanese Cancer Association. 55 Annual Meeting. 441 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 近藤泰理: "抗アンドロゲン剤CasodexのAMN(N-Amyl-N-methylnitrosamine)ラット実験食道癌において発癌抑制効果" 日本癌学会総会記事. 第55回. 441- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 近藤泰理: "非ステロイド性抗アルドロゲン剤CasodexのAMNCN-Auyl-N-wethylvitrosauice" 第45回日本癌学会総会記事. 73 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] KONDOH Y,OGOSHI K,MIYAJIM,IWATA K,TAJiMA T,MITOMI T: "INHIBiTORY EFFECT OF FLUTAMIDE ON EXPERIMENTAL OESOPHAGEAL CANCER INDUCED BY N-AMYL-N-METHYLNITROSAMINE(AMN)IN RATS" XXIX WORLD CONGRESS of the FNTERNATIONAL COLLEGE OF SURGEONS. 76- (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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