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Protective effect of ADF in reperfusion injury after canine by transplantation

Research Project

Project/Area Number 06671340
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

YOKOMISE Hiroyasu  Kyoto University Chest Disease Research Institute Thoracic Surgery, Assistant Prof., 胸部疾患研究所, 助手 (80231728)

Co-Investigator(Kenkyū-buntansha) INUI Kenji  Kyoto University Chest Disease Research Institute Thoracic Surgery, Associate, 講師 (10193567)
WADA Hiromi  Kyoto University Chest Disease Research Institute Thoracic Surgery, Associate Pr, 助教授 (90167205)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
KeywordsTransplantation Lung / Ischemia reperfusion injury / ADF / human Thioredoxin / 虚血再潅流障害
Research Abstract

Human thioredoxin, which was previously recognized as adult T-cell leukemia-derived factor, has many physiologic activities, one of which is a radical scavenger effect. Its ability to reduce reperfusion injury was assessed in vivo in a canine lung transplantation model. In 19 dogs, left lung allotransplantation was performed after 100 minutes of warm ischemia. The function of the transplanted lung was assessed after clamping of the contralateral pulmonary artery. In the human thioredoxin group (n=6), human thioredoxin 30 mg/kg was given to the recipients during reperfusion. In the N-acetylcysteine group (n=5), N-acetylcysteine 150 mg/kg, known as a radical scavenger, was given in the same manner. In both groups, arterial oxygen tension was significantly higher than in the control group (n=8). In the human thioredoxin group, peak inspiratory pressure was significantly lower than in the control group. Macroscopic and microscopic examinations showed an almost normal appearance of the lung tissues in the human thioredoxin and N-acetylcysteine groups, in contrast to the abnormal findings in the control group. Thus it would appear that human thioredoxin has a protective effect on transplanted lungs, as does N-acetylcysteine, and that its action may be a radical scavenger effect.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Kazuyuki Tagi. et al: "Inhibition of reperfusion injury by human thioredixin (adult T-cell leukemia-derived factor)in canine lung transplantation." J. Thorac. Cardiovasc Surg.108. 913-921 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tastuo Fukuse. et al: "Attenuation of ischaemia reperfusion injury by human thioredoxin." Thorax.50. 387-391 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyasu yokomise et al: "Effect of recombinant human adult T-cell leukemia-derived factor on rat lung reperfusion injury." Respiration. 61. 99-104 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiromi Wada. et al: "Effect of the combination of human thioredoxin and 1-cysteine on ischemia-reperfusion injury an isolated rat lung." Europ. Surg. Res.27. 363-390 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuyuki Yagi. et al.: "Inhibition of reperfusion injury by human thioredixin (adult T-cell leukemia-derived factor) in canine lung transplantation." J.Thorac Cardiovasc Surg.108. 913-221 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tastuo Fukuse. et al.: "Attenuation of ischaemia reperfusion injury by human thioredoxin." Thorax. 50. 387-391 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyasu yokomise. et al.: "Effect of recombinant human adult T-cell leukemia-derived factor on rat lung reperfusion injury." Respiration. 61. 99-104 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiromi Wada.et al: "Effect of the combination of human thioredoxin and 1-cysteine on ischemia-reperfusion injury an isolated rat lung." Europ.Surg.Res.27. 363-390 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi K, et al: "Inhibition of reperfusion injury by human thioredoxin(adult T-cell leukemia-derived factor)in canine lung transplantation." J Thorac Cardiovasc Surg. 108. 221-910 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Fukuse T et al: "Attenuation of ischaemia reperfusion injury by human thioredoxin." Thorax. 50. 387-391 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H Yokomise et al: "Effect of recombinant human adult T cell leukemia-derived factor on rat lung reperfusion injury." Respiration. 61. 99-104 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiromi Wada. et al: "Effect of the combination of human thioredoxin and 1-cysteine on ischemia-reperfusion injury an isolated rat lung." Europ. Surg. Res.27. 363-370 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Yagi.et al.: "Inhibition of reperfusion injury by human thioredoxin(adult T-cell leukemia-derived facttor)in canine lung transplantation" J.Thorac.Cardiovasc.Sivg. 108. 913-21 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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