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Development of vascular prostheses for coronary artery bypass grafting in which microporous strucure induces serum protein layr formation and accelerates endothelialization

Research Project

Project/Area Number 06671364
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTeikyo University

Principal Investigator

OKOSHI Takafumi  Teikyo University, Second Department of Surgery, Assistant Professor, 医学部, 講師 (50185237)

Co-Investigator(Kenkyū-buntansha) NOSHIKI Yasuharu  Yokohama City University, First Department of Surgery, Assistant Professor, 医学部, 講師 (60033263)
AKASAKA Tadayoshi  Teikyo University, Second Department of Surgery, Professor, 医学部, 教授 (70167815)
EGOH Yoichi  Teikyo University, Second Department of Surgery, Associate Professor, 医学部, 助教授 (10246035)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsMicroporous structure / Small diameter vascular prosthesis / Coronary artery bypass grafting / Polyurethane vascular prosthesis / Hydraulic permeability / Endothelialization / 内皮化
Research Abstract

The influence of microporous structures in a material surface and wall on patency and endothelialization of small diameter vascular grafts for aorto-coronary bypass grafting was investigated. Six types of spongy polyurethane-polydimethylsiloxane grafts (PUG), 1.5 mm internal diameter (ID), 1.5-2 cm in length, were implanted end-to-end in the infrarenal aorta of adult rats. Some had a continuous inner skin and a hydraulic permeability (HP) of 0 ml/min/cm^2/120 mmHg (PUG-S-0). Some had a discontinuous inner skin with some isolated windows (pores) which connect penetrating micropores though the graft wall and a mean HP ranging from 11 (PUG-S-11) to 37 (PUG-S-37) or 58 (PUG-S-58) ml/min/cm^2/120 mmHg. Some had a microporous inner surface with penetrating micropores through the graft wall and a mean HP of 2.7 (PUG-2.7) or 39 (PUG-39) ml/min/cm^2/120 mmHg. PUG which had a HP of less than 2.7 ml/min/cm^2 showed poor patency. PUG with a HP of more than 11 ml/min/cm^2/120 mmHg had acceptable patency. Endothelialization was limited to their anastomoses in PUG-S-11. In contrast, the patent PUG-S-37 and PUG-S-58 were largely endothelialized and all but one of the patent PUG-39 were completely endothelialized. Moreover, a spongy polyurethane vascular graft with a microporous inner surface (ID : 1.5 mm, length : 10 cm, HP : 146 ml/min/cm^2/120 mmHg) was implanted in a loop shape in the rat abdominal aorta and patent at 232 days after implantation. Thus, penetrating micropores through the graft wall appear to inhibit thrombo-occlusion of the grafts. A microporous inner surface seems to be superior in achieving a high degree of endothelialization.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Takafumi Okoshi: "New Concept of Microporous Structure in Small Diameter Vascular Prosteses." Artificial Organs. 19. 27-31 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文: "人工血管の進歩" 外科診療. 37. 199-204 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "ポリエポキシ化合物処理生体弁の右心系および左心系における抗血栓性の検討" 人工臓器. 23. 133-136 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "クオリティ・オブ・ライフの向上を目指した変性し難い柔軟な生体弁の開発-左心系における抗血栓性の評価-" 日本心臓血圧研究振興会平成四・五年度研究業績集. 24-29 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "ミクロ多孔質構造により内面に自然に血清蛋白層を形成させて内皮化を促進させるA-Cバイパス用人工血管" 日本心臓血圧研究振興会平成六年度研究業績集. 21-23 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "漏水性を備えたミクロ多孔質ポリウレタン製小口径人工血管" 人工臓器. 25. 193-196 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yasuharu Noishiki et al: "Rapid Neointima Formation with Elastic Laminae Similar to the Natural Arferial Wall on an Adipose Tissue Tragmenfed Vascular Prosthesis" ASAIO Journal. 40. 267-272 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 野一色泰晴 他: "自家組織細切片移植技術を用いたA-Cバイパス用人工血管の開発-天然血管壁に近い構造をもつ新生内膜形成を目指して-" 日本心臓血圧研究振興会平成四・五年度研究業績集. 1-8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takafumi Okoshi et al: "Penetrating micropores in crease patency and achieve extensive endothelialization in small diameter skinned vascular grafts" ASAIO Journal. 42(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "ミクロ多孔質構造により内面に自然に血清蛋白層を形成させて内皮化を促進させるA-Cバイパス用人工血管-長期植え込み実験成績-" 日本心臓血圧研究振興会平成七年度研究業績集. (印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 冨澤康子 他: "人工血管の注射針を用いた穿刺に関する一考察" 人工臓器. 25. 230-233 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 冨澤康子 他: "皮下に植え込まれた人工血管の治癒過程におけるbFGFの動向" 人工臓器. 25. 443-447 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takafumi Okoshi et al: "Encyclopedia of Biomaterials and Bioengineering" Marcel Dekker,Inc., 1832 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takafumi Okoshi et al: "Heart Replacement-Artificial Heart 5" Springer-Verlag, 424 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "Annual Review循環器" 中外医学社, 298 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takafumi Okoshi et al: "Heart Replacement-Artificial Heart 6" Springer-Verlag (in press),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大越隆文 他: "看護必携シリーズ 第5巻 外科I" 学習研究社, 514 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al.: "Nonthrombogenicity of a polyepoxy compound-crosslinked heart valve in the right and left heart systems." Jpn J Artif Organs. 23. 133-136 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al.: "Development of pliable bioprosthetic heart valve with reduced degeneration for improvement of the quality of life of the patients after heart valve replacement -Evaluation of nonthrombogenicity in the left heartt system." Transactions of Japan Research Promotion Society for Cardiovascular Diseases. 1992-1993. 24-29 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Noishiki, et al.: "Development of a vascular prosthesis for coronary bypass grating using autologous tissue fagment transplanation technology. For a neointima similar to the narural arterial wall" Transactions of Japan Research Promotion Society for Cardiovascular Diseases. 1992-1993. 1-8 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Noishiki, et al.: "Rapid neointima formation with elastic laminae similar to the natural arterial wall on an adipose tissue fragmented vascular prosthesis" ASAIO Journal. 40. 267-272 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T: "New concept of microporous structure in small diameter vascular prostheses" Artificial Organs. 19. 27-31 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T: "Progress in development of vascular grafts" Geka-shinryo. 37. 199-204 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T et al.: "Vascular prostheses for coronary artery bypass grafting in which microporous structure induces nonthrombogenicity by naturally adsorped serum protein layr and accelerates endothlialization" Transactions of Japan Research Promotion Society for Cardiovascular Diseases. 1994. 21-24 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al: "Microporous polyurethane small diameter vascular prostheses with hydraulic permeability" Jpn J Artif Organs. 25. 193-196 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al: "Penetrating micropores increase patency and achieve extensive endothelialization in small diameter skinned vascular grafts" ASAIO Journal. 42(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi, et al: "Vascular prostheses for coronary artery bypass grafting in which microporous structure induces nonthrombogenicity by naturally adsorbed serum protein layr and accelerates endothelialization. -Long-term animal study-" Transactions of Japan Research Promotion Society for Cardiovascular Diseases. 1995(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomizawa Y,et al: "Healing process after needle puncture of biologic vascular grafts : Experimental study" Jpn J Artif Organs. 25. 230-233 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomizawa Y,et al: "Basic fibroblast growth factor in non-functioning vascular grafts : Experimental study." Jpn J Artif Organs. 25. 443-447 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T: Hybrid small diameter vascular grafts.Annual Review Junkanki 1995, 258-261 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al: New Frontiers of Biomaterials for Cardiovascular Surgery. Encyclopedic Handbook of Biomaterials and Bioengineering. Marcel Dekker, Inc., 1153-1170 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al: Microporous polyurethane inhibits critical mural thrombosis and enhances endothelialization at blood-contacting surface. Heart Replacement -Artifical Heart 5. Springer Verlag, Tokyo Japan, 47-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al: Arteiosclerosis obliterance. Handbook of Nursing -No 5, Surgery I, 480-491 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okoshi T,et al: Influence of microporous structures on mural thrombosis and endothelialization at blood-contacting surface Heart Replacement -Artifical Heart 6. Springer Verlag, Tokyo Japan : (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takafumi Okoshi: "New concept of Microporous Structure in Small Diameter Vascular Prothesis" Artificial Organs. 19. 27-31 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大越隆文: "人工血管の進歩" 外科診療. 37. 199-204 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大越隆文他: "ミクロ多孔質構造により内面に自然に血清蛋白質層を形成させて内皮化を促進させるA-Cバイパス用人工血管" 日本心臓血圧研究振興会平成六年度研究業績集. 21-23 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大越隆文他: "漏水性を備えたミクロ多孔質ポリウレタン製小口径人工血管" 人工臓器. 25. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takafumi Okoshi et al: "Encyclopedia of Biomaterials and Bioengineering" Marcel Dekker, Inc., 1832 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大越隆文他: "Annual Review循環器" 中外医学社, 298 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takafumi Okoshi: "New Concept of Microporous Structure in Small Diameter Vascular Prostheses" Artificial Organs. 19. 27-31 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大越 隆文: "人工血管の進歩" 外科診療. 37. 199-204 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大越 隆文他: "ポリエポキシ化合物処理生体弁の右心系および左心系における抗血栓性の検討" 人工臓器. 23. 133-136 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大越 隆文他: "クオリティ・オブ・ライフの向上を目指した.変性し難い柔軟な生体弁の開発-左心系における抗血栓性の評価-" 日本心臓血圧研究振興会 平成四・五年度研究業績集. 24-29 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yasuharu Noishiki et al: "Rapid Neointima Formation with Elastic Laminae Similar to the Natural Arterial Wall on an Adipose Tissue Fragmented vascular Prosthesis" ASAIO Journal. 40. 267-272 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野一色 泰晴 他: "自家組織細切片移植技術を用いたA-C Bypass用人工血管の開発-天然血管壁に近い構造をもつ新生内膜形成を目指して-" 日本心臓血圧研究振興会 平成四・五年度研究業績集. 1-8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takafumi Okoshi et al: "Encyclopedia of Biomaterials and Bioengineering" Marcel Dekker,Inc., (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大越 隆文 他: "Annual Review 循環器" 中外医学社, 298 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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