| Project/Area Number |
06671366
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
FUJIWARA Takashi Kawasaki Medical School, Medical Engineering, Professor, 医学部, 教授 (90090224)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Masami Kawasaki College of Allied Health Professions, Medical Electronics, Associate Pr, 医用電子技術科, 助教授 (50148699)
OGASAWARA Yasuo Kawasaki Medical School, Medical Engineering, Assistant Professor, 医学部, 講師 (10152365)
TSUJIOKA Katsuhiko Kawasaki Medical School, Medical Engineering, Professor, 医学部, 教授 (30163801)
KAJIYA Fumihiko Kawasaki Medical School, Medical Engineering, Professor, 医学部, 教授 (70029114)
矢田 豊隆 川崎医科大学, 医学部, 助手 (00210279)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | intramyocardial slosh phenomenon / coronary artery stenosis / myocardial ischemia / high frequency ultrasound pulsed Doppler velocimeter / intra-aortic balloon pumping / vascular endothelial funciton / 高周波数超音波ドップラー血流速度計 |
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| Research Abstract |
With increasing severity of cardiac diseases for cardiac operation, intra-aortic balloon pumping has been frequently used for these patients. Evaluation of the effect of intraaortic balloon pumping on the phasic blood velocity waveform into myocardium with coronary artery stenosis revealed followings : In the presence of severe coronary artery stenosis, intra-aortic balloon pumping failed to increase the diastolic inflow to the myocardium and did not enhance the systolic retrograde flow from the myocardium to the extramural coronary artery. Thus, the major effect of intra-aortic balloon pumping on the ischemic heart with severe coronary stenosis may be achieved by reducing oxygen demand by the systolic unloading. Since there are increasing number of studies indicating that the vascular endothelial function is disturbed in patients with coronary risk factors, including hypertension and hyperlipidemia, we have evaluated the influence of endothelial dysfunction on the intramyocardial circulation and the effect of intra-aortic ballon pumping on it. With intracoronary administration of N^<omega>-nitro-L arginine (L-NNA,2 mumol/min) in dogs, the effects of intra-aortic balloon pumping on the intramyocardial vessels were significantly attenuated. It is also shown that endothelium-derived nitric oxide plays roles in intramyocardial regulation of vascular diameter and its pulsation.
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