Gene Expression and Gene Therapy Trial In Intra-Amygdaloid Kainic Acid Epilepsy Model
| Project/Area Number |
06671391
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tottori Univ.School of Medicine, Dept.of Neurosurgery |
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Principal Investigator |
KONDO Shinji Tottori Univ.School of Medicine, Dept.of Neurosurgery, 医学部・附属病院, 助手 (60192069)
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| Co-Investigator(Kenkyū-buntansha) |
KAMITANI Hideki Tottori Univ.School of Medicine, Dept.of Neurosurgery, 医学部・附属病院, 助手 (70194967)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | KAINIC ACID / APOPTOSIS / EPILEPSY / てんかんモデル / immediute early gene |
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| Research Abstract |
We have evaluated the hypothesis that apoptosis can cause hippocampal cell death induced by intra-amygdaloid injection of kainic acid (KA) in rats, which is an animal model of the hippocampal sclerosis in human temporal epilepsy. With in situ end labeling method, we have examined as early as 18h post KA injection nuclear staining located in the CA3 area of the hippocampus ipsilateral to the injection site. By the seventh day post KA injection, most of the ipsilateral pyramidal cells were positive. It is suggested that the distant brain damage originated from the amygdala by KA injection could induce apoptoic cell death in the ipsilateral hippocampus.
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Report
(3 results)
Research Products
(3 results)
