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Radiosensitizing effects of a new photosensitizer ATX-S10

Research Project

Project/Area Number 06671393
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

ISOBE Naoyuki (1995)  Hiroshima University, Medical Hospital, Research Associate, 医学部・附属病院, 助手 (20271570)

矢野 隆 (1994)  広島大学, 医学部・附属病院, 講師 (20239825)

Co-Investigator(Kenkyū-buntansha) KURISU Kaoru  Hiroshima University, School of Medicine, Professor, 医学部, 教授 (70201473)
磯部 尚幸  広島大学, 医学部, 医員
門田 秀二  広島大学, 医学部, 助手 (50263687)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsATX-S10 / Radiosensitizer / Brain edema / Malignant brain tumor / 光化学療法 / 光感受性物質
Research Abstract

Radiosensitizing effects of a new photosensitizer ATX-S10
1. Intracranial and systemic distribution of ATX-S10 in malignant brain tumor model
The intracranial and systemic distribution of a new photosensitizer, four-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio-porphynyl (IX) -6-2-bisaspartic acid (ATX-S10) in experimental rat brain tumor model (9L gliosarcoma) were investigated with emphasis on the distribution in the peritumoral edematous region, and compared it with concentration on tumor, normal brain and serum. The results were as follows.
1. The accumulation of ATX-S10 on tumor was very high, while that on peritumoral edematous region was relatively low and that on normal brain was extremely low.
2. The accumulation of ATX-S10 on serum was higher than that on tumor.
On the basis of this result of its intracranial distribution, we propose the usefulness of ATX-S10 for the photodynamic treatment of malignant brain tumors.
2. Radiosensitizing effects of ATX-S10
The in vitro and in vivo investigations showed no radiosensitizing effects. As a result, ATX-S10 has no radiosensitizing effects for the treatment for malignant brain tumors.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 門田秀二: "光感受性物質「ATX-S10」の悪性脳腫瘍モデルにおける脳内および全身への分布動態の検討" 広島大学医学雑誌. 43. 77-85 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 磯部尚幸: "ラットグリオーマ頭蓋内移植モデルに対するTNP-470とCDDP併用による抗腫瘍効果の検討-腫瘍の組織学的変化を中心に-" Bio theray. 9. 440-441 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 磯部尚幸: "ラットグリオーマに対するTNP-470による抗腫瘍効果の検討" Bio therapy. 8. 478-479 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shuji Mouden: "Intracranial and Systemic Distribution of New Photo sensitizer ATX-S10 in Malignant Brain Tumor Model." Hirdai ishi. 43. 77-85 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Naoyuki Isobe: "Autitumor Effect of Combination Chemotherapy with TNP-470 and CDDP on Intracranial Tumor Transplanted in Rats. -Histological Changes of Intratumoral Tissue-" Biotherapy. 9. 440-441 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Naoyuki Isobe: "Antitumor Effect of TNP-470 on Glioma Transplanted in Rats." Biotherapy. 8. 478-479 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 門田秀二: "光感受性物質「ATX-S10」の悪性脳腫瘍モデルにおける脳内及び全身への分布動態の検討" 広島大学医学雑誌. 43. 77-85 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 磯部尚幸: "ラットグリオーマ頭脳内移植モデルに対するJNP-470とCDDP併用による抗腫瘍効果の検討-組織学的変化を中心に-" Biotherapy. 9. 440-441 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 門田秀二: "光感受性物質「ATX-S10」の悪性脳腫瘍モデルにおける脳内及び全身への分布動態の検討" 広島大学医学雑誌. 43. 77-85 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 門田秀二: "水溶性Pheophorbide-aの実験脳腫瘍モデルにおける分布動態の検討-特に腫瘍部と脳浮腫部の比較について-" 第14回 日本レーザー医学会大会 大会論文集. 14. 329-332 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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