| Project/Area Number |
06671409
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University School of Medicine |
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Principal Investigator |
YAMAMOTO Isao Yokohama City University, Department of Neurosurgery, Professor, 医学部, 教授 (30158266)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Hironobu Yokohama City University, Department of Neurosurgery, Instructor, 医学部, 助手 (90254226)
SATO Masazumi Yokohama City University, Department of Neurosurgery, Instructor, 医学部, 助手 (70244473)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | hypertension / nucleus tractus solitarius / C1 cell group / microvascular decompression / C_1 cell group |
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| Research Abstract |
(Materials & Methods)
Thirty-four rat were anesthetized under respirator and oxygen flow adjusted to maintain blood gases and PH within physiological limits. The animals were placed prone to expose the ventrolateral medulla to permit insertion of silicone microballon beneath the axilla of the IXth & Xth cranial nerves. The sites of balloon compression were as followings : a) right ventrolateral medulla (Rt-VLM) with an electrolytic lesion at Cl-cell group, b) Rt-VLM without an electrolytic lesion, c) left (Lt) -VLM with an electrolytic lesion at C1 -cell group, d) Lt-VLM without an electrolytic lesion, e) Rt-&Lt-VLMs with bilateral electrolytic lesions at Cl-cell groups.
(Results)
Balloon inflation caused a significant elevated blood pressure not only Rt but also Lt-side compression. There were also no definite difference in changing blood pressure between with and without an electrolytic lesion at Cl-cell group.
(Conclusion)
These experimental results using rats did not support the clinical evidence, that was the relief of preoperative long-standing hypertension after the mobilization of an arterial loop on the area anterior to the left IXth & Xth cranial nerves.
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