Analysis of Cerebral disorders using functional MRI
| Project/Area Number |
06671427
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Meiji College of Oriental Medicine |
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Principal Investigator |
TANAKA Chuzo Meiji College of Oriental Medicine Neurosurgery Prtofe, 鍼灸学部, 教授 (80163541)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Toshihiro Kyoto Prefectural University of Medicine Neurosurgery Assistant Professor, 医学部, 助手 (80218700)
UMEDA Masahiro Meiji College of Oriental Medicine Neurosurgery Lectur, 鍼灸学部, 講師 (60223608)
EBISU Toshihiko Meiji College of Oriental Medicine Neurosurgery Lectur, 鍼灸学部, 講師 (40278510)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Functional MRI / Brain mapping / Brain activation / Echo planar imaging / BOLD effect / Cerebral perfusion imaging / fMRI / functional mapping / cerebral furction / EPI / Cerebral Perfusion / Deoxy-Hb |
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| Research Abstract |
Functional brain mapping was performed with somatosensory stimulation, motor task, and visual stimulation using echo planar imaging with a conventional 1.5 T MRI apparatus in order to clarify the distribution of activated area induced by each stimulation.
Five normal volunteers were instructed to oppose fingers each other at the frequency of 3 Hz for motor task, right median nerve electro-stimulation was performed, and a roller for acupuncture was applied on palm as a pure somatosensory stimulation. These motor task and sensory stimulation studies were performed successively for each hand and for each volunteer. Three normal volunteers were studied with reversing checcurboard pattern for visual stimulation. MRI were obtained using a 1.5 Tesla conventional MRI apparatus (Signa Horizon, GE) with standard head coil. One shot multislice (four slices) echo-planar imaging (EPI) sequence was employed to obtain images. MRI data were analyzed by cross correlation thresholding using MR vision software (Stanford University).
Full Visual field stimulation caused activation of bilateral occipital lobe including both primary and secondary visual cortex in all three cases. Stimulation of right half or left half of visual field caused activation of contralateral occipital lobe including both primary and secondary visual cortex.
It was hard to detect the activated brain area in median nerve electro-stimulation, only one case out of five cases caused indistinct activation at contralateral cortex around central sulcus. On the other hand, both roller stimulation and motor task provoked distinct activated areas at contralateral peri central sulcus (over 0.6 of correlation coefficient) in all cases. Consequently, the activated area at contralateral peri-central sulcus by both motor task and somatosensory stimulation occupied almost the same area, which suggests the possibility of the intermixed localization of the primary motor area and the primary somatosensory area.
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Report
(3 results)
Research Products
(17 results)
