| Project/Area Number |
06671443
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | NIIGATA UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
DOHMAE Youichiro NIIGATA UNIVERSITY SCHOOL OF MEDICINE Associate Prof, 医学部, 助教授 (80227701)
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| Co-Investigator(Kenkyū-buntansha) |
TANIZAWA Tatuhiko Niigata University SCHOOL OF MEDICINE Associate Prof, 医学部・附属病院, 講師 (90227231)
ENDO Naoto Niigata University SCHOOL OF MEDICINE, 医学部・附属病院, 助手 (10251810)
TAKAHASHI Hideaki Niigata University SCHOOL OF MEDICINE Professor, 医学部, 教授 (50018397)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | human bone marrow cell / CFU-F / osteoprogenitor cell / Histomorphometry / ヒト骨髄細胞 / 骨形成能 / アルカリフォスフォターゼ |
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| Research Abstract |
Undifferntiated mesenchymal cells in bone marrow differentiate to form CFU-Fs in vitro, and some of CFU-Fs show osteoblastic features. The effect of growing and aging on the number of CFU-F harvested from ilium in human was examined. The number of ALP positive CFU-Fs was high undr 18 years of age, and gradual decline in the number was observed with aging.
Secondly, the effect of BMP-2 on the CFU-F was examined. BMP-2 affected the differentiation of osteoprogenitor cells (ALP positive CFU-F), suggesting that BMP-2 could be one of potent stimulators to differentiate osteoprogenitor cells into osteoblasts.
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