| Project/Area Number |
06671445
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
MATSUI Hisao TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY,Department of Orthopaedic Surgery, Associate Professor, 医学部, 助教授 (20173784)
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| Co-Investigator(Kenkyū-buntansha) |
KANAMORI Masahiko TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY,Department of Orthopaedic Surgery,, 医学部, 助手 (20204547)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Cauda equina / Lumbar laminectomy / Vascular permeability / Adhesive arachnoiditis / Nutritional supply |
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| Research Abstract |
To clarify the early histological changes of lumbar adhesive arachnoiditis, we evaluated vascular permeability changes in the cauda equina after laminectomy in rats. Wistar rats laminectomized from L5 to L6 were divided into the following five series : 1. Evans blue albumin tracer study 2. Lanthanum tracer study 3. Horseradish peroxidase distribution 4. Fluorescent isothiocyanate-dextran tracer study, and 5. Supply and diffusion of ^3H-methylglucose in the cauda equina and other organ tissues after intravenous injection was evaluated in the laminectomized rats with kaolin administration on the dura mater. Untreated rats were used as control. Laminectomy induced an increase of vascular permeability of the cauda equina especially at laminectomized area. There were aggravated intercellular active transportation in the endothelial cell and opening of the tight junction at an early stage following laminectomy. The permeability aggravation was correlated with the adhesion of the cauda equina. There was an increase of isotopes distribution (percent of blood DPM) in the cauda equina of rats which was administrated kaolin compared with control rats. These results suggest that minimization of the extradural inflammation after laminectomy may reduce the occurrence of postoperative lumbar adhesive arachnoradiculitis.
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