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MECHANISMS AND INHITION OF THE INVASION OF MALIGNANT BONE AND SOFT TISSUE TUMORS THROUGH BASEMENT MEMBRANES

Research Project

Project/Area Number 06671462
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

IWAMOTO Yukihide  KYUSHU UNIVERSITY,MEDICAL DEPT., ASSOCIATE PROFESSOR, 医学部, 助教授 (00213322)

Co-Investigator(Kenkyū-buntansha) 泉 敏弘  九州大学, 医学部, 助手 (90253426)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsMALIGNANT TUMOR / BONE AND SOFT TISSUE / METASTASIS / BASEMENT MEMBRANES / INVASION / 異性腫瘍 / 規定膜
Research Abstract

Tumor invasion of the basement membranes is a crucial step in the complex multistage process which leads to the formation of metastasis. Tumor cells cross the basement membranes as they initially invade vascular beds during dissemination, and then they penetrate their target tissue. The treatment of human fibrosarcoma cells HT1080 with cAMP analogues and chorela toxin that increase the intra-cellular cAMP concentrations induces the expression of Timp-1 and Timp-2 both at the mRNA and the protein levels. This induction of Timps correlated well with type IV collagenolytic activity, invasiveness and metastatic potential of HT1080 cells.
We developed a quantitative assay for assessing in vivo tumor angiogenesis using basement membrane extracts (Matrigel). Nude mice are injected s.c. with liquid Matrigel mixed with HT1080 cells. Since Matrigel forms a solid gel rapidly at body temperature, the gel containing tumor cells can be removed immediately, and the processed for histological studies. Tumor angiogenesis was monitored quantitatively by measuring both the number and total area of neovessels present in the gels using an image analyzer.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (83 results)

All Other

All Publications (83 results)

  • [Publications] Y. Iwamoto, et al.: "In vitro assay of the invasive potential of malignant bone and sofy tissue tumors through basement membranes." International Orthop.18. 240-247 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Okuyama, Y. Iwamoto, et al.: "The inhibition of the invasion of human fibrosarcoma cells by cyclic AMP analogues and cholera toxin." The Cancer J.7:. 150-157 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Miyashi, Y. Iwamoto, et al.: "The effects of cisplatin on the epiphyseal growth plate." International J.Oncology. 4:. 1105-1109 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Fujita, Y. Iwamoto, et al.: "Drug-induced endothelial iniury potentiates lung colonization in a murine fibrosarcoma model." International J. Oncology. 4:. 1305-1310 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Iwamoto, et al.: "Role laminin on the invasion of HT1080 human fibrosarcoma cells through basement membranes." Transactions of the 40th Annual Meeting of Orthopaedic Research Society.758 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Okuyama, Y. Iwamoto, et al.: "Cyclic AMP analogues and cholera toxin inhibit the invasion of human fibrosarcoma cells." Transactions of the 40th Annual Meeting of Orthopaedic Research Society.759 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "Cyclic AMP-induced synthesis of tissue inhibitor of metalloproteinases suppress the in vasive potential of the human fibrosarcoma cell line HT1080." Cancer Res.55:. 2927-2935 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "The establishment and characterization of a peripheralneuroepithelioma cell line in soft tissue of extremity." Laboratory Investigation. 72:. 237-248 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Ito, Y. Iwamoto, et al.: "A quantitative assay using basement membraneextracts to study tumor angiogenesis in vivo." International J. Cancer.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Naka, Y. Iwamoto, et al.: "Osteosarcoma versusmalignant fibrous histiocytoma of bone in patients older than 40 years." Cancer. 76:. 972-984 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Iwamoto, et al.: "Three-dimentional MRI reconstruction of musculoskeletal tumors. A preliminary evaluation of 2 cases." Acta Orthop. Scand.66:. 80-83 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Iwamoto, et al.: "Role of MR imaging in the diagnosis of alveolar soft part sarcoma:A report of 10 cases." Skeletal Radiology. 24:. 267-270 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英、伊藤康正。: "腫瘍血管新生の分子機構とその制御" BIO clinica. 11巻. 60-62 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Ito, Y. Iwamoto, et al.: "A new method using basement membraneextracts to stuidy tumor angiogenesis in vivo." Transactions of the 41st Annual Meeting of Orthopaedic Research Society.208 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "Induction of TIMPs by elevation of intracellular cyclic AMP concentration in hibits the invasiveness of human fibrosarcoma cells." Transactions of the 41st Annual Meeting of Orthopaedic Research Society.278 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "Comparison of the effects of intra-arterial and intravenous cisplatin on foot tumors and survival of rats bearing lung metastases." Transactions of the 41st Annual Meeting of Orthopaedic Research Society.437 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Naka, Yukihide Iwamoto, et al.: Human Pathology. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英、小田義直。: "悪性線維性組織球腫(MFH)" Orthopaedics Today. (印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英。: "悪性形質" 成形外科:. 63巻. 1786 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 中馬広一、岩本幸英、ほか。: "再発、再燃した悪性骨軟部腫瘍に対する化学療法の検討" 整形外科と災害外科:. 43巻. 765-767 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英: "原発性骨悪性腫瘍切除後の再建に対する同種骨の応用." 骨関接靱帯:. 7巻. 343-348 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英。: "四肢の転移性骨腫瘍に対する手術療法:集学的治療の中での位置付けについて." Therapeutic Research:. 15巻. 419-423 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英。: "同種骨移植による再建: Massive segmental allograft" 整形・災害外科. 38巻. 825-831

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英。: "日本における同種骨移植の現状" 整形外科. 63巻. p1786 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英、小田義直。: "新版図説臨床整形外科講座13巻「骨軟部腫瘍および類似疾患」、(腫瘍と間違えやすい軟部病変)" メディカルレビュー社、東京, 350(319-326) (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岩本幸英。: "OS NOW 18 :骨腫瘍の診断と治療(肺転移に対する治療-肺転移の抑制、治療)" メディカルレビュー社、東京, 241(236-241) (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Okuyama, Y.Iwamoto, et al.: "The inhibition of the invasion of human fibrosarcoma cells by cyclic AMP analogues and choleratoxin." The Cancer J.7. 150-157 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Miyoshi, Y.Iwamoto, et al.: "The effects of cisplatin on the epiphyseal growth plate." International J.Oncology. 4. 1105-1109 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Fujita, Y.Iwamoto, et al.: "Drug-induced endothelial injury potentiates lung colonization in a murine fibrosarcoma model." International J.Oncology. 4. 1305-1310 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iwamoto, et al.: "In vitro assay of the invasive potential of malignant bone and soft tissue tumors through basement membranes." Inernational Orthop.18. 240-247 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iwamoto, et al.: "Role of laminin on the invasion of HT1080 human fibrosarcoma cells through basement membranes." Transactions of the 40th Annual Meeting of Ortopaedic Research Society. 758 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Okuyama, Y.Iwamoto, et al.: "Cyclic AMP analogues and cholera toxin inhibit the invasion of human fibrosarcoma cells." Transactions of the 40th Annual Meeting of Orthopaedic Research Society. 759 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Tanaka, Y.Iwamoto, et al.: "The establishment and characterization of a peripheral neuroepithelioma cell line in soft tissue of extremity." Laboratory Investigation. 72. 237-248 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Tanaka, Y.Iwamoto, et al.: "Cyclic AMP-induced synthesis of tissue inhibitor of metalloproteinases suppress the in vasive potential of the human fibrosarcoma cell line HT1080." Cancer Res.55. 2927-2935 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Naka, Y,Iwamoto, et al.: "Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years." Cancer. 76. 972-984 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iwamoto, et al.: "Three-dimentional MRI reconstruction of musculoskeletal tumors. A preliminary evaluation of 2 cases." Acta Orthop.Scand.66. 80-83 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iwamoto, et al.: "Role of MR imaging in the diagnosis of alveolar soft part sarcoma : A report of 10 cases." Skeletal Radiology. 24. 267-270 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Ito, Y.Iwamoto, et al.: "A new method using basement membrane extracts to study tumor angiogenesis in vivo." Transactions of the 41st Annual Meeting of Orthopaedic Research Sjociety. 208 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Tanaka, Y.Iwamoto, et al.: "Induction of TIMPs by elevation of intracellular cyclic AMP concentration inhibits the invasiveness of human fibrosarcoma cells." Transactions of the 41st Annual Meeting of Orthopaedic Research Society. 278 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Tanaka, Y.Iwamoto, et al.: "Comparison of the effects of intra-arterial and intravenous cisplatin on foot tumors and survival of rats bearing lung metastases." Transactions of the 41st Annual Meeting of Orthopaedic Research Society. 437 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Ito, Y.Iwamoto, et al.: "A quantitative assay using basement membrane extracts to study tumor angiogenesis in vivo." International J.Cancer. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Naka, Yukihide Iwamoto, et al.: "Proliferative activities in conventional chordoma. A clinicopathologic, DNA flow cytometric and immunohistochemical analysis of 17 cases with special reference to anaplastic chordoma showing a diffuse proliferation and nuclear atypia." Human Pathology. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. iwamoto, et al.: "In vitro assay of the in vasive potential of malignant bone and soft tissue tumors through basement membranes." International Orthop.18. 240-247 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Okuyama, Y. Iwamoto, et al.: "The inhibition of the invasion of human fibrosarcoma cells by cyclic AMP analogues and cholera toxin." The Cancer J.7. 150-157 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Miyoshi, Y. Iwamoto, et al.: "The effects of cisplatin on the epiphyseal growth plate." International J. Oncology. 4. 1105-1109 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Fujita, Y. Iwamoto, et al.: "Drug-induced endothelial injury potentiates lung colonization in a murine fibrosarcoma model." International J. Oncology. 4. 1305-1310 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Iwamoto, et al.: "Role of laminin on the invasion of HT1080 human fibrosarcoma cells through basement menbranes." Transactions of the 40th Annual Meeting of Orthopaedic Research Society,. 758 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Okuyama, Y. Iwamoto, et al.: "Cyclic AMP analogues and cholera toxin inhibit the invasion of human fibrosarcoma cells." Transactions of the 40th Annual Meeting of Orthopaedic Research Society,. 759 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "Cyclic AMP-induced synthesis of tissue inhibit or of metalloproteinases suppress the in vasive potential of the human fibrosarcoma cell line HT1080." Cancer Res.55. 2927-2935 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "The establishment and characterization of a peripheral neuroepithelioma cell line in soft tissue of extremity." Laboratory Investigation. 72. 237-248 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Ito, Y. Iwamoto, et al.: "A quantitative assay using basement menbraneextracts to study tumor angiogenesis in vivo." International J. Cancer. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Naka, Y. Iwamoto, et al.: "Osteosarcoma versusmalignent fibrous histiocytoma of bone in patients older than 40 years." Cancer. 76. 972-984 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Iwamoto, et al.: "Three-dimentional MRI reconstruction of musculoskeletal tumors. A preliminary evaluation of 2 cases." Acta Orthop. Scand.66. 80-83 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Iwamoto, et al.: "Role of MR imaging in the diagnosis of alveolar soft part sarcoma: A report of 10 cases." Skeletal Radiology. 24. 267-270 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英、伊藤康正: "腫瘍血管新生の分子機構とその制御" BIO clinica. 11巻. 60-62 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Ito, Y. Iwamoto, et al.: "A new method using basement membraneextracts to study tumor angiogenesis in vivo." Transactions of the 41th Annual Meeting of Orthopaedic Research Society,. 208 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "Induction of TIMPs by elevation of intracellular cyclic AMP concentration inhibits the invasiveness of human fibrosarcoma cells." Transactions of the 41st Annual Meeting of Orthopaedic Research Society,. 278 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Tanaka, Y. Iwamoto, et al.: "Comparison of the effects intra-arterial and intravenous cisplatin on foot tumors and survival of rats bearing lung metastases." Transactions of the 41st Annual Meeting of Orthopaedic Research Society,. 437 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Naka, Yukihide Iwamoto, et al.: Human Pathology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英、小田義直: "悪性線維性組織球腫(MFH)" Orthopaedics Today. (印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英: "悪性形質" 整形外科. 63巻. 1786 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中馬広一、岩本幸英、ほか: "再発、再燃した悪性骨軟部腫瘍に対する化学療法の検討" 整形外科と災害外科. 43巻. 765-767 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英: "原発性骨悪性腫瘍切除後の再建に対する同種骨の応用" 骨関接靱帯. 7巻. 343-348 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英: "四肢の転移性骨腫瘍に対する手術療法:集学的治療の中での位置付けについて." Therapeutic Research.15巻. 419-423 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英: "同種骨移植による再建:Massive segmental allograft" 整形・災害外科. 38巻. 825-831

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英: "日本における同種骨移植の現状" 整形外科. 63巻. 1786 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英、小田義直: "新版図説臨床整形外科講座13巻「骨軟部腫瘍および類似疾患」、(腫瘍と間違えやすい軟部病変)" メジカルビュー社、東京, 319-326 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩本幸英: "OS NOW 18:骨腫瘍の診断と治療(肺転移に対する治療-肺転移の抑制、治療)" メジカルビュー社、東京, 236-241 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yukihide Iwamoto: "Use of an in vitro assay to study the invasiveness of malignant bone and soft tissue tumors through basementmembranes." International Orthopaedics. 18. 240-247 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kiyotaka Okuyama: "The inhibition of the invasion of human fibrosarcoma cells by cAMP analogues and cholera toxin." The Cancer Journal. 7. 150-157 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshinori Fujita: "Drug-induced endothelial injury potentiates lung colonization in a murine fibrosarcoma model." International Journal of Oncology. 4. 1305-1310 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ken-ichi Miyoshi: "Effect of cisplation on the epihyseal growth plate." International Journal of Oncology. 4. 1105-1109 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshinao Oda: "Giant cell reparative granuloma arising in enchondromatosis.A case report." Skeletal Radiology. 23. 669-671 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yukihide Iwamito: "Three-dimentional reconstruction of musculoskeletal tumors." Acta Orthop Scand. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yukihide Iwamito: "Role of MR imaging in the diagnosis of alveolar soft part sarcoma:A report of 10 cases." Skeletal Radiology. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuhiro Tanaka: "The establishment and characterization of a peripheral neuroepithelioma cell line in soft tissue of extremity." Laboratory Investigation. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takeshi Arizono: "Ethylene oxide sterilization of bone grafts.Residual gas concentration and fibroblast oxicity." Acta Orthop Scand. 65. 640-642 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩本幸英: "四肢の転移性骨腫瘍に対する手術療法:集学的治療の中での位置付けについて" Therapeutic Research. 15. 419-423 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩本幸英: "原発性骨悪性腫瘍切除後の再建に対する同種骨の応用." 骨関節靱帯. 7. 343-348 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩本幸英: "骨軟部腫瘍の3次元再構築" 整形外科と災害外科. 43. 630-633 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 中馬広一: "再発、再燃した悪性骨軟部腫瘍に対する化学療法の検討" 整形外科と災害外科. 43. 765-767 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩本幸英: "悪性形質" 整形外科. 63. 1786-1786 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩本幸英: "腫瘍と間違えやすい軟部病変" 新版、図説臨床整形外科講座. 13(印刷中). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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