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Pathomechanism of radicular pain in lumbar radiculopathy.

Research Project

Project/Area Number 06671473
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionWakayama Medical College, School of Medicine

Principal Investigator

KAWAKAMI Mamoru  Wakayama Medical College, Orthop.Surg., Assistante, 医学部, 助手 (20195051)

Co-Investigator(Kenkyū-buntansha) TAMAKI Tetsuya  Wakayama Medical College, Orthop.Surg., Professor, 医学部, 教授 (30009592)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsNucleus Pulposus / Anulus Fibrosus / Pain / Hyperalgesia / Phospholipase A2 / Nitric Oxide / Mepacrine / L-NAME / L-NAME / pH / インターロイキン
Research Abstract

Fat, nucleus pulposus (NP) and anulus fibrosus (AF) were allografted into the epidural space at L_6 level in the rat. Withdrawal response thresholds to mechanical stimuli and withdrawal response latencies to thermal stimuli on the tail postoperatively. Interleukin-1, PLA_2 and NOS were examined in the applied tissues using immunohistochemistry, NADPH-diaphorase histochemistry and in situ hybridization. In results, allografted fat did not produce hyperalgesia. Allografts of NP and NP+AF showed evidence of mechanical and thermal hyperalgesia, respectively. Although interleukin-1 was demonstrated in all applied tissues, PLA_2 was only observed around the applied NP and NP+AF.NOS was only markedly increased around the applied. The NP group (allografted NP placed on the sciatic nerve) and NP+AF group (NP+AF,respectively) were mede to evaluate the sensitivities to noxious stimuli following local sciatic nerve administration of L-NAME or mepacrine into the operated site. Only rats in the NP group showed evidence of mechanical hyperalgesia. Injection of L-NAME resulted in evidence of mechanical hyperalgesia in the NP+AF group. Mechanical hyperalgesia, which was produced in the NP group and after injection of L-NAME in the NP+AF group, both of which returned to normal after mepacrine injection. In conclusion, it appears that PLA_2 and NO play important but different roles in pathomechanisms of radicular pain in lumbar disc herniation.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 川上守: "椎間板組織による疼痛発現に及ぼす一酸化窒素、Phospholipase A2の役割" 日整会誌. 69. 51443 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mamoru Kawakami: "Pathomechanim of pain related behavior produced by allografts of intervertebral disc in the rat." Spine. 21. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mamoru Kawakami: "The role of phospholipase A2 and nitric oxide in pain related behavior produced by application of intervertebral disc to the sciatic nerve in the rat." Transaction of Orthopedic Research Society. 43. 188 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mamoru Kawakami: "The difference in nociceptive potential of the nucleus pulposus and the anulus fibrosus.New Horizons of Low Back Pain" Weinstein & Gordon, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawakami M,Tamaki T,Weinstein J,Hashizume H,Nishi H,Meller S,Gebhart GF: "Disc materials produce pain-related behavior in the rat : The role of pH,immune response and chemicals" Tansactions of Orthopaedic Research Society. 20 (2). 666 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mamoru Kawakami, Tetsuya Tamaki, Hiroshi Hashizume, James N.Weinstein, Stephen T Meller: "The role of phospholipase A2 and nitric oxide in pain related behavior produced by application of intervertebral disc to the sciatic nerve in the rat" Transactions of Orthopaedic Research Society. 21 (1). 188 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Hashizume, Tetsuya Tamaki, Mamoru Kawakami, Hideto Nishi, Emiko Senba: "Nitric oxide in lumbar disc herniation-Histochemical study" Transactions of Orthopaedic Research Society. 21 (2). 685 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawakami M,Tamaki T,Weinstein JN,Hashizume H,Nishi H,Meller ST: "Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat" Spine. (In Press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mamoru Kawakami, James N.Weinstein, Tetsuya Tamaki, Hiroshi Hashizume: "The difference in nociceptive potential of the nucleus pulposus and the amulus fibrosus" New Horizons in Low Back Pain.AAOS Publications. (In Press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 川上守: "椎間板組織による疼痛発現に及ぼす一酸化窒素、phospholipase A2の役割" 日本整形外科学会雑誌. 69(8). S1443- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mamoru Kawakami: "Pathomechanism of pain related behavior produced by allografts of intervertebral disc in the rat." Spine. 21(accepted). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mamoru Kawakami: "The role of phospholipase A2 and nitric oxide in pain related behavior produced by application of intervertebral disc to the sciatic nerve in the rat." Transaction of Orthopedic Research Society.43. 188- (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mamoru Kawakami: "The difference in nociceptive potential of the nucleus pulposus and the anulus fibrosus.New Horizon of Low Back Pain" Weinstein & Gordon(accepted), (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川上 守: "腰部椎間板ヘルニアの疼痛発現機序-硬膜外髄核移植による知覚過敏-" 中部日本整形外科災害外科学会雑誌. 37. 1215-1216 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mamoru Kawakami: "Disc materials produce pain-related behavior in the rat" Transaction of Orthopedic Research Society. 42. 666- (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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