| Project/Area Number |
06671479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical School |
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Principal Investigator |
TAKAHASHI Kuniyasu Department of Orthpaedic Surgery, Saitama Medical Center, Saitama Medical School, Assistant, 医学部, 助手 (80188002)
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| Co-Investigator(Kenkyū-buntansha) |
TSUZUKI Nobuyuki Department of Orthpaedic Surgery, Saitama Medical Center, Saitama Medical School, 医学部, 教授 (10049794)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Cervical nerve root / Dorsal root ganglion / Sensory nerve ending / Cervical radicular pain / 疼痛 / 自由神経終末 / 神経終末 / 神経鞘 |
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| Research Abstract |
The presence and distribution of nerve endings in the dural sheath of cervical nerve roots (dural root-sheaths) was investigated histopathologically using 39 cervical root-dorsal root ganglion specimens obtained from 18 postmortem examinations within 12 hours after death. Ages ranged from 4 months to 88 years, with a mean of 58 years. Microscopic investigation was conducted using 20 mum serial sections of various parts of the dural root-sheath, stained by the Suzuki silver impregnation method or Kluver-Barrera method. Free nerve endings were identified in each of the dural root-sheaths of the anterior root, posterior root and dorsal root ganglia (DRG), including the septum, and two types of sensory corpuscles were identified in each of the dural root-sheaths of the dorsal root ganglia and the septum. The fiber diameters of free nerve endings corresponded to those of either Adelta-fibers or C-fibers. The distribution of free nerve endings was greater in the proximal and distal portions of the DRG sheath than in other parts of the dural root-sheath. The largest population of free nerve endings with C-fibers in the DRG sheath was 12 in a tissue cylinder with a volume of 0.01 mm^3 (0.16mm^2*0.06mm), with an average of 3.7. These nerve endings were found to follow either of two centripetal routes, one through a sinuvertebral nerve and the other through small nerves which penetrated directly into the DRG from nerve endings. The number of free nerve endings in the dural root-sheath increased with ages (gamma=0.75). In addition, the number of free nerve endings in subjects below the age of sixty was lower than that of subjects above sixty with a statistical significance (p=0.019). These free nerve endings in the dural root-sheath, especially those in the DRG sheath, are thought to play an important role in the mediation of cervical radicular pain.
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