| Project/Area Number |
06671489
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
TOMITA Yoshitsugu Jikei University School of Medicine, Dept.of Orthopaedics, Associate Professer., 医学部, 助教授 (80056788)
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| Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Shigeru Jikei University School of Medicine, Dept.of Orthopaedics, Senior surgeon, 医学部, 助手 (00239633)
ROPPONGI Satoshi Jikei University School of Medicine, Dept.of Orthopaedics, Senior surgeon, 医学部, 助手 (30201130)
SUGIYAMA Hajime Jikei University School of Medicine, Dept.of Orthopaedics, Lecturer, 医学部, 講師 (40196770)
KANAO Yutaka Jikei University School of Medicine, Dept.of Orthopaedics, Lecturer, 医学部, 講師 (00169541)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Allograft / Bone Graft / beta-Tricalcium Phosphate / Bone Remodelling / New Bone Formation / Bone Stock / 同種骨移植 / 骨伝導 / bone stock / β-TCP / THA |
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| Research Abstract |
In the revision surgery of total hip prostheses, the lack of bone stoch is one of the serious problems, Recently, big allograft is often used to replace the big cavity in the acetabular part after removal of the protheses. However, the collapse tends to be seen in the allograft above the acetabular 4 or 5 years after revision surgery. To prevent this collapse in the allograft, beta-Tricalcium phosphate (beta-TCP) were used in it, because the beta-TCP is an excellent , aterial which introduces early bone formation while, during bone remodeling prosess, itself gradually degradates and is finelly replaced by new bone. Columner allografts (5cm*4cm) were taken in the condyle of the femur of the Newzealand rabbit, and it was kept in -80ﾟC as the donor. And next, same size hole were made in the condyle of the bilateral femur of white rabbits, and then the same size solumner allograft was inserted in the hole, as the control group and the allograft in which beta-TCP were packed in the center (phi1.6mm) as beta-TCP group.4&10weeks after surgery, animals were harvested and the speciments were investigated in new bone formation. In 10 weeks tremendous new bone formation were found in beta-TCP group. beta-TCP is really useful for new bone formation in the allograft in revision THA.
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