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Experimental study of adhesive spinal arachnoiditis.

Research Project

Project/Area Number 06671493
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionFujita Health University

Principal Investigator

YOSHIZAWA Hidezo  Fujita Health Univ, Orthopaedic surgery, Professor, 医学部, 教授 (60084555)

Co-Investigator(Kenkyū-buntansha) UKAI Takahiro  Fujita Health Univ, Orthopedic surgery, Assistant professor, 医学部, 講師
KOBAYASHI Shigeru  Fujita Health Univ, Orthopaedic surgery, Assistant professor, 医学部, 講師 (80234821)
NAKAI Sadaaki  Fujita Health Univ, Orthopaedic surgery, Assistant professor, 医学部, 講師 (10247645)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
KeywordsSpinal cord / Syringomyelia / Arachnoiditis / Blood-spinal barrier / 血液・脊髄関門
Research Abstract

In this study, we prepared an animal model of spinal adhesive arachnoiditis by injecting Kaolin into the subarachnoid space of rabbits. The animals were sacrificed 4 months later, and changes of the spinal cord and the subarachnoid space were examined. Of the 22 rabbits given Kaolin injection into the cerevrospinal fluid, 3 showed partial obstruction of the subarachnoid space nd 19 showed complete circumferential obstruction. In the rabbits with partial obstruction, intramedullary changes and dilatation of the central canal were not observed. However, among the 19 animals showing complete obstruction, dilatation of the central canal (hydromyelia) occured in 14 and an intramedullary syrinx was observed in 9. In animals with complete obstruction, fluorescence microscopy revealed intramedullary edema around the central canal an extending to the posterior column. Since such changes were not present in animals with only partial obstruction of the subarachnoid space, these changes were not d … More ue to disturbance of the arterial system but rather to impairment of the venous system which is easily affected by increased pressure. Scanning electron microscopy revealed a marked reduction of villi on the ependymal cells lining the dilated central canals. Transmission electron microscopy revealed separation of the ependymal cells. Scanning and transmission electron microscopy of sringomyelia revealed that nerve fibers and nerve cells were exposed on the surface of the syrinx, and there was no clear border with the medullary tissue. Around the syrinx, abnormal verve fibers and nerve cells were observed, and a scavenging necrotic tissue. In other words, since there is little neural regeneration in the spinal cord, it seems that necrotic tissue is removed by macrophages to leave a syrinx (syringomyelia). There are two types of syringomyelia, i.e.hydromyelia, which is dilation of the central canal, and syringomyelia, which is a syrinx with no connection to the central canal. The two types differ in their mechanism of development : hyromyelia is attributed to disturbed reflux of cerebrospinal fluid, while tissue necrosis due to disturbed intramedullary blood flow is considered to be deeply involved in formation of the syrinx in syringomyelia. Less

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 吉沢英造: "脊髄血流と髄液流" 日独医報. 40. 84-95 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西本聡: "慢性髄液停滞が脊髄に及ぼす影響について" 日本パラプレイジラ医学会誌. 7. 76-77 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西本聡: "MRIで促えた外傷性脊髄浮腫と思われる1例" 東海脊椎外科. 8. 100-101 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 中井定明: "脊髄空洞を伴う脊柱側彎症の検討" 脊柱変形. 9. 86-90 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hidezo Yoshizawa: "On the effects of the ligation of multiple odzacent radicular vessels on spihal cord function in dogs" Neuro Orthopaedics. 17/18. 121-129 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤桂: "脊髄癒着性くも膜炎モデルにおける実験的研究血管透過性及び組織学的変化" 中部整災誌. 38. 1533-1534 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤桂: "脊髄全周性くも膜下腔閉塞が脊髄に及ぼす影響" 厚生省特定疾患脊柱靭帯骨化症調査研究班平成6年度研究報告書. 133-137 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hidezo Yoshizawa: "Blood supply of spinal cord and cerebrospinal fluid flow." Nitidoku-Ihou. 40. 84-95 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hidezo Yoshizawa, Yasuhiro Fujiwara, Shigeru Kobayashi, Sadaaki Nakai: "On the effects of the ligation of multiple adjacent radicular vessels on spinal cord function in dogs." Neuro-Orthopaedics. 17/18. 121-129 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katura Kato, Hidezo Yoshizawa, Shigeru Kobayashi, Motohiro Kojima: "Experimental study of spinal adhesive arachnoiditis. Changes of blood permeability and histological view." Cent Jpn J Orthop Traumatol. 38. 1533-1534 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katura Kato, Hidezo Yoshizawa, Shigeru Kobayashi: "Effects of circumferential obstructed subarachnoid space on the spinal cord." Investigation committee report on the ossification of the spinal ligaments of the japanese ministry of public health and welfare. 133-137 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshikazu Fujimura, Hidezo Yoshizawa, Kiyoshi Hirabayashi, Takashi Sakou, Eiji Taketomi: "Operative report on the ossification of the posterior longuitudinal ligament of the thoracic spine." Investigation committee report on the ossification of the spinal ligaments of the japanese ministry of public health and welfare. 217-192 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shigeru Kobayashi: "Effects of spinal cord and nerve root on cerebrospinal fluid flow." Nitidoku-Ihou. 41. 260-277 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katura Kato, Hidezo Yoshizawa, Shigeru Kobayashi: "Effects of obstructed subarachnoid space on the spinal cord. Scanning electron microscopic study." Investigation committee report on the ossification of the spinal ligaments of the japanese ministry of public health and welfare. 190-192 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 吉沢英造: "脊柱靱帯骨化症における髄内変化に関する実験的研究" 愛知県特定疾患研究協議会研究報告書(平成6年度). 21 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小林茂: "脳脊髄液が脊髄・神経根に及ぼす影響について" 日独医報. 41. 260-277 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 加藤桂: "クモ膜下腔閉塞が脊髄に及ぼす影響について-走査型電子顕微鏡による観察-" 厚生省特定疾患、脊柱靱帯骨化症調査研究班、平成7年度研究報告書. 190-192 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 吉沢英造: "脊柱靱帯骨化症における髄内変化に関する実験的研究" 愛知県特定疾患研究協議会研究報告書(平成7年度). 23 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 加藤 桂: "脊髄全周性くも膜下腔閉塞が脊髄に及ぼす影響" 厚生省特定疾患 脊桂靱帯骨化症調査研究班、平成6年度研究報告書. 133-137 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 吉沢英造: "脊髄血流と髄液流" 日独医報. 40. 84-95 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 加藤 桂: "脊髄癒着性くも膜炎モデルにおける実験的研究-血管透過性及び組織学的変化-" 中部整災誌. 38. 1533-1534 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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