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Periodical changes of muscle cells and peripheral sensory nerve endings after denervation.

Research Project

Project/Area Number 06671496
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKAWASAKI MEDICAL SCHOOL

Principal Investigator

KOSHIMA Isao  Plast. Reconstr. Surg. KAWASAKI MEDICAL SCHOOL,Associate Professor, 医学部, 助教授 (60101804)

Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Keywordsdenervated muscle / sensory terminal / vascularized nerve graft / vascularized muscle transfter
Research Abstract

1. Experimentally, it was observed that regeneration following degeneration of the gastrocunemius muscle cells after rat's sciatic nerve transection.
2. In the denervated Pacinian corpuscles, experimentally and clinically, it was detected that the terminal axons disappeared, but the outer core cells existed for long time.
3. Based on the experimental and cadeveric results, free vascularized long nerve grafts and vascularized muscle transfer with a long motor nerve have been clinically developed for repair of untreatable established nerve paralysis.
4. Free vascularized split or divided muscle transfer has been also developed for one-stage reconstruction of more complicated dynamic motor function.
5. These new original operation methods seem to have a potential for reconstruction of major paralysis of spinal cord injuries.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (56 results)

All Other

All Publications (56 results)

  • [Publications] Koshima Isao: "Free rectus femoris muscle transfer of one‐stage reconstruction of established facial paralysis." Plast. Reconstr. Surg.94(3). 421-430 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "The combined anterior and posterior tibial perforator‐based flap with a vascularized deep peroneal nerve for repair of facial defect." Ann. Plast. Surg.33(4). 421-425 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 光嶋勲: "手の神経再建" 形成外科(増刊号). 37. 213-217 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 光嶋勲: "遊離合併型組織移植の進歩と今後の展望" 形成外科. 37(11). 1223-1233 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 光嶋勲: "陳旧性顔面神経麻痺に対する神経血管柄付遊離大腿直筋移植による一期的再建術" Facial Nerve Research Japan. 14. 93-96 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "Flow‐through anterior thigh flaps for one‐stage reconstruction of soft tissue defects and revascularization of ischemic extremities." Plast. Reconstr. Surg.95(2). 252-260 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 江藤久志: "神経血管付きhemi‐pulp flapを用いて再建した左中指化学熱傷後瘢痕拘縮の1例" 形成外科. 38(3). 263-268 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "Free combined thin wrap‐around flap with a second toe proximal interphalangeal joint transfer for reconstruction of the thumb." Plast. Reconstr. Surg.96(5). 1205-1210 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 光嶋勲: "神経縫合後の創傷治癒:最近の話題を中心に" 形成外科. 38(11). 1173-1185 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "Free vascularized deep peroneal nerve grafts." J. Reconstr. Microsurg.12(3). 131-141 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "Three‐dimensional reconstruction for complex facial defects following cancer ablation." J. Reconstr. Microsurg.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "A double muscle transfer using a divided rectus femoris for facial paralysis reconstruction." J. Reconstr. Microsurg.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 光嶋勲: "整形・形成外科診療Q&A" 六法出版社, 1171ノ2-1171ノ5 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Moriguchi Takahiko, Soeda Shugo, Hamanaka Takaomi, Tanaka Hiroshi, Ohta Shigeo: "Free rectus femoris muscle transfer for one-stage reconstruction of established facial paralysis" Plast. Reconstr. Surg.94 (3). 421-430 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Yamamoto Hidekazu, Moriguchi Takahiko, Kawada Shinsaku, Ono Yoko: "The combined anterior and posterior tibial perforator-based flap with a vascularized deep peroneal nerve for repair of facial defect" Ann. Plast. Surg.33 (4). 421-425 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Kawada Shinsaku, Etoh Hisashi, Kawamura Susumu, Moriguchi Takahiko, Sonoo Hiroshi: "Flow-through anterior thigh flaps for one-stage reconstruction of soft tissue defects and revascularization of ischemic extremities" Plast. Reconstr. Surg.95 (2). 252-260 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Kawada Shinsaku, Etoh Hisashi, Saisho Hiroshi, Moriguchi Takahiko: "Free combined thin wrap-around flap with a second toe proximal interphalangeal joint transfer for reconstruction of the thumb." Plast. Reconstr. Surg.96 (5). 1205-1210 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Okumoto Kazuo, Umeda Naoto, Moriguchi Takahiko, Ishii Ryoji, Nakayama Yoshio: "Free vascularized deep peroneal nerve grafts." J.Reconstr. Microsurg.12 (3). 131-141 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Hosoda Masaru, Moriguchi Takahiko, Ishii Ryoji, Orita Yozo, Yamamoto Hidekazu: "Three-dimensional reconstruction for complex facial defects following cancer ablation." J.Reconstr. Microsurg.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao, Umeda Naoto, Handa Toru, Moriguchi Takahiko, Orita Yozo: "A double muscle transfer using a divided rectus femoris muscle for facial paralysis reconstruction." J.Reconstr. Microsurg.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koshima Isao: "Scarpa's adipofascial flap for repair of wide scalp defects." Ann.Plast.Surg.36(1). 88-92 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "Ultrastructural observation of lymphatic vessels in lymphedema in human extremities." Plast.Reconstr.Surg.97(2). 397-405 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 光嶋勲: "遊離組織移植による指・手皮膚欠損の被覆" 形成外科. 39(3). 289-296 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "Free vascularized deep peroneal nerve grafts." J.Reconstr.Microsurg.12(3). 131-141 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 光嶋勲: "膝関節部の皮弁の実際(特集:四肢における皮弁の実際)" 整形・災害外科. 39(5). 535-544 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 光嶋勲: "血管柄付き遊離爪移植による爪再建。特集:爪の疾患・外傷による爪変形の治療" Monthly Book Orthopaedics. 9(9). 53-59 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 光嶋勲: "リンパ浮腫の治療,特集:一般・消化器外科医のための形成外科手術手技の要点" 手術. 50(10). 1715-1723 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 光嶋勲: "Perforator-based flap(穿通動脈皮弁),-より犠牲の少ない皮弁を求めて-" 形成外科. 39(10). 981-992 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "Free medial thigh perforator-based flaps : new definition of the pedicle vessels and versatile application." Ann.Plast.Surg.37(5). 507-515 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "Three-dimensional reconstruction for complex facial defects following cancer ablation." J.Reconstr.Microsurg.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "A full-thickness chondrocutaneous flap from the auricular concha for repair of tracheal defect." Plast.Reconstr.Surg.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "A double muscle transfer using a divided rectus femoris muscle for facial paralysis reconstruction." J.Reconstr.Microsurg.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 光嶋勲: "形成外科ADVANCEシリーズ,マイクロサージャリー最近の進歩" 克誠堂, 40-49 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "Donald Serafin's Atlas of Microsurgical Composite Tissue Transplantation" W.B.Saunders Company, 430-432 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koshima Isao: "Persistent elevation of TNF-α in burn patients may contribute to compromised wound healing." Kawasaki Medical Journal. 20 (3-4). 79-85 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "耳介を用いた気管の再建:遊離血管柄付耳甲介移植" 医学の歩み. 175 (7). 492-493 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "神経縫合後の創傷治癒:最近の話題を中心に" 形成外科. 38 (11). 1173-1185 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "頭頸部腫瘍手術の基本手技" 頭頸部腫瘍. 21 (3). 543-547 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koshima Isao: "The radial artery perforator-based adipofascial flap for dorsal hand coverage." Ann. Plast. Surg.35 (5). 474-479 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "腹直筋穿通動脈皮弁による頭頸部再建" 日耳鼻咽会報. 98 (1). 1-7 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koshima Isao: "Flow-through anterior thigh flaps for one-stage reconstruction of soft tissue defects and revascularization of ischemic extremities." Plast. Reconstr. Surg. 95 (2). 252-260 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "神経血管付きhemi-pulp flapを用いて再建した左中指化学熱傷後瘢痕拘縮の1例" 形成外科. 38 (3). 263-268 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "遊離皮弁による舌、口底再建症例の術後機能評価" 頭頸部腫瘍. 21 (1). 70-76 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koshima Isao: "Connected deep femoral and gluteal perforator-based flap for repair of extensive defect on the posterior thigh." Plast. Reconstr. Surg. 96 (1). 201-206 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koshima Isao: "Free combined thin wrap-around flap with a second toe proximal interphalangeal joint transfer for reconstruction of the thumb." Plast. Reconstr. Surg. 96 (5). 1205-1210 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "外傷性顔面神経麻痺の処置について.整形・形成外科診療Q&A" 六法出版社, 1171ノ2-1171ノ5 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koshima Isao: "The anterolateral thigh flap (chapter 40), Discussion. Atlas of Microsurgical Composite Tissue Transplantation." Saunders, 430-432 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "血管柄付キメラ型遊離合併組織移植による下顎の再建.骨移植、最近の進歩" 克誠堂, 120-126 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 光嶋 勲: "手の瘢痕拘縮、前腕・手、新図説臨床整形外科講座 第8巻" メディカルビュー, 260-267 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koshima Isao: "Reinnervation of denervated Pacinian corpuscles:Ultrastructural observations in rats following freenerve grafts." Plast.Reconstr.Surg.92(4). 728-735 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Koshima Isao: "Freerectus femoris muscle transfer for one-stage reconstruction of established facial paralysis." Plast.Reconstr.Surg.94(3). 421-430 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Koshima Isao: "The combined anterior and posterior tibial perforator-based flap with a vascularized deep peroneal nerve for repair of facial defect." Ann.Plast.Surg.33(4). 421-425 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 光嶋 勲: "手の神経再建" 形成外科(増刊号). 37. 213-217 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 光嶋 勲: "陳旧性顔面神経麻痺に対する神経血管柄付遊離大腿直筋移植による一期的再建術" Facial Nerve Research Japan. 14. 93-96 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 光嶋 勲: "神経の創傷治療.形成外科ADVANCEシリーズ,創傷の治療,最近の進歩" 克誠堂, 74-85 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 光嶋 勲: "外傷性顔面神経麻痺の処置について。六法出版整形・形成診療Q&A" 六法出版(印刷中), (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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