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Physio-Pharmacological Effects of Analgesics and Sedatives on Respiratory Depression

Research Project

Project/Area Number 06671510
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

ITO Yusuke (1995)  Toyama Medical and Pharmaceutical University Department of Anesthesiology, Professor, 医学部・麻酔科学, 教授 (70018307)

増田 明 (1994)  富山医科薬科大学, 医学部・麻酔科学, 助教授 (30126552)

Co-Investigator(Kenkyū-buntansha) MASUDA Akira  Toyama Medical and Pharmaceutical University Department of Anesthesiology, Assoc, 医学部・麻酔科学, 助教授 (30126552)
伊東 祐輔  富山医科薬科大学, 医学部・麻酔科学, 教授 (70018307)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
KeywordsRespiration / Respiratory depression / Human volunteer / Benzodiazepine / Midazolam / Flumazenil / Heart rate spectral analysis / Stellate ganglion block / Human / Flumazenil / Respiratory depresion
Research Abstract

In the first year, we investigated the effects of sevoflurane on the phrenic nerve discharge and the respiratory timing compared with those of halothane in cats. These findings demonstrated that sevoflurane has a weaker depressive effect on the respiratory nerve discharge and a smaller effect on the neural respiratory rate than halothane. This may be due to the lesser effect of sevoflurane on the vagal mediated and CO2-related mechanisms which modulate the global outputs of the central respiratory control systems (1).
In the second year, we also investigated the respiratory effects of benzodiazepine (midazolam) in healthy volunteers. This data suggests that flumazenil reverses midazolam-induced sedation completely but is partially effective for some parameters related to respiratory depression (2). It also demonstrated the difference in midazolam-induced sedation and breathing patterns between male and female subjects with midazolam administration on a mg/kg basis (3).
To investigate the cardiac autonomic nervous system related to respiratory depression, we conducted a preliminary study in healthy volunteers under right or left stellate ganglion block (SGB). The findings suggest that right SGB stimulates the cardiac autonomic nervous system and left SGB suppress it (4-6). We will study that effect of midazolam on the cardiac autonomic nervous system in due time.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 増田 明: "健常人におけるミダゾラムの呼吸抑制作用とフルマゼニルによる拮抗作用" 麻酔. 43. 722-727 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "Sinus arrest after right stellate ganglion block" Anesthesia & Analgesia. 79. 607- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 増田 明: "星状神経節ブロックによる洞停止の1症例-心拍変動の周波数解析から-" 麻酔. 44. 858-861 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 若杉雅浩: "QT延長症候群患者に対する星状神経節ブロックの影響" ペインクリニック. 16. 287-288 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "Effects of sevoflurane on respiratory activities in the phrenic nerve of decerebrate cats." Acta Anaesthesiol Scand. 39. 774-781 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "Flumazenil antagonism of midazolam-induced respiratory depression." Masui. 43. 722-727 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "Differences in midazolam-induced breathing patterns in healthy volunteers." Acat Anaesthesiol Scand. 39. 785-790 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "Sinus arrest after right stellate ganglion block." Anesth Analg. 79. 604 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "A transient sinus arrest after right stellate ganglion block-assessment of autonomic function by heart rate spectraol analysis-." Masui. 44. 858-861 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Wakasugi: "Effect of stellate ganglion block in a patient with long QT syndrome." Pain clinic. 16. 287-288 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Masuda: "Effect of sevoflurane on respiratory activities in the phrenic nerve of decerebrate cats" Acta Anaesthesiologica Scandinavica. 39. 774-781 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田 明: "健常人におけるミダゾラムの呼吸抑制作用とフルマゼニルによる拮抗作用" 麻酔. 43. 722-727 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Masuda: "Differences in midazolam-induced breathing patterns in healthy volunteers" Acta Anaesthesiologica Scandinavica. 39. 785-790 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Masuda: "Sinus arrest after right stellate ganglion block" Anesthesia & Analgesia. 79. 607- (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田 明: "星状神経節ブロックによる洞停止の1症例-心拍変動の周波数解析から-" 麻酔. 44. 858-861 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 若杉雅浩: "QT延長症候群患者に対する星状神経節ブロックの影響" ペインクリニック. 16. 287-288 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田明: "健常人におけるミダゾラムの呼吸抑制作用とフルマゼニルによる拮抗作用" 麻酔. 43. 722-727 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] A.Masuda: "Effect of sevoflurane on respiratory activities in the phrenic nerve of decerebrate cats" Acta Anaesthesiologica Scandinavica. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] A.Masuda: "Differences in midazolam-induced breathing patternsin healthy volunteers" Acta Anaesthesiologica Scandinavica. (in press).

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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