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Chaotic analysis of autonomic nervous activities during anesthesia

Research Project

Project/Area Number 06671515
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya University

Principal Investigator

KIMURA Tomomasa  Nagoya University, Anesthesiology, Assistant Professor, 医学部, 講師 (50161568)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsAutonomic nerve / Chaos / Heart rate variability / Anesthetics / Fractal / Correlation dimension / 吸入麻酔薬 / イオンチャネル / 人工膜
Research Abstract

The mechanism of action of inhalational anesthetics is unknown, but neuronal membrane alteration with chaotic purturbations caused by anesthetics is a favored hypothesis. In order to evaluate whether or not HRV have both periodic and deterministic-chaotic properties in conscious and anesthetized states, we analyzed HRV by power spectral analysis and methods of deterministic chaos.
A predominant deterministic-chaotic structure of HRV with high fractal correlation dimension during conscious states altered to a more periodic structure and lower correlation dimension during general anesthesia with sevoflurane or halothane. In addition, major thoracic surgery, such as esophagectomy or pulmonary resection, diminished fractal features of HRV,suggestiong that fractal component could be an estimate of recovery state from surgical invasion.
Neural control of cardiovascular system, thus, shows featrues associated with deterministic chaos by analyzing HRV changes. These results indicated the dynamic cardiovascular system that are partly characterized by non-linear natures typical for chaotic systems.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 小松 徹、木村 智政 他: "麻酔と自律神経活動モニター -心拍変動周波数解析の麻酔深度モニターへの応用" 病態生理. 12. 631-643 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村 智政: "麻酔深度と心拍変動周波数解析を指標とした自律神経応答." 医学のあゆみ. 168. 702-703 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, T., etc.: "Autonomic imbalance of the heart during total spinal anesthesia evaluated by spectral analysis of heart rate variability." Anesthesiology. 80. 309-312 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村 智政: "心拍変動 -周波数解析を中心に." 医学のあゆみ. 173. 1011-1015 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村 智政: "麻酔薬の心拍変動におよぼす影響." 日本臨床麻酔学会誌,. 15. 462-467 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Komatsu, T., Singh, PK., Kimura, T., etc: "Differential effects of ketamine and midazolam on heart rate variability." Can.J.Anaesth.,. 42. 1005-1009 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, T., Komatsu, T., その他: "Autonomic imbalance of the heart during total spinal anesthesia evaluated by spectral analysis of heart rate variability." Search on Anesthesia,. 3. 10-11 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, T., その他: "Alterations in spectral characteristics of heart rate variability as a correlate of cardiac autonomic dysfunction after esophagectomy or pulmonary resection." Anesthesiology,. 84. 1068-1076 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村 智政 その他: "重症患者の自律神経系バイオシグナル" ICUとCCU. 20. 185-194 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 木村 智政: "心電図RR間隔変動における非線形成分の成因機序の解明とその臨床応用" 福田記念医療技術振興財団情報第8号. 9-15 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村 智政: "手術侵襲と神経系" 麻酔. 46. S16-S24 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村 智政: "手術侵襲と生体の反応-反応の経路-3.神経系.麻酔と手術侵襲-免疫・内分泌・自律神経系からみた21世紀への提言" 小川 龍、弓削 孟文、細川 豊史 編 真興交易医書出版部,東京, 19 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, T., Komatsu, T., Hirabayashi, A., Sakuma, I., Shimada, Y.: "Autonomic imbalance of the heart during total spinal anesthesia evaluated by spectral analysis of heart rate variability." Anesthesiology. 80. 309 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Komatsu, T., Singh, PK., Kimura, T., Nishiwaki, K., Bando, K., Shimada, Y.: "Differential effects of ketamine and midazolam on heart rate variability." Can.J.Anaesth.42. 1005 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, T., Komatsu, T., Hirabayashi, A., Sakuma, I., Shimada, Y.: "Autonomic imbalance of the heart during total spinal anesthesia evaluated by spectral analysis of heart rate variability." Search on Anesthesia. 3. 10 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, T., Komatsu, T., Takezawa, J., Shimada, Y.: "Alterations in spectral characteristics of heart rate variability as a correlate of cardiac autonomic dysfunction after esophagectomy or pulmonary resection." Anesthesiology. 84. 1068 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Komatsu, T., Kimura, T.: "Surgical invasion and nervous system." Masui. 46. S16 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小松 徹、木村智政: "麻酔薬の心拍変動におよぼす影響" 日臨麻誌. 15. 462-457 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 小松 徹、木村智政: "生体情報の新しいモニタリング、心拍変動-周波数解析を中心に" 医学のあゆみ. 173. 1011-1015 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Toru Komatsu,Tomomasa Kimura,etc: "Differential effects of ketamine and midazolam on heart rate variability." Can J Anaesth. 42. 1003-1009 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 木村信行、木村智政、他: "麻酔深度モニターとしての心拍変動カオス解析" 臨床モニター. 7(Supl). 47 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Komatsu.T,Kimera.T et al: "Fractal dimensionality of heart rate variability after coronary artery surgery" Aneathesiology. 81. A337-A337 (1984)

    • Related Report
      1994 Annual Research Report
  • [Publications] Komatsu.T,Kimura.T,et al: "Simultaneous analysis of absolute and fractional power spectra of heart rate variability is needed during anesthesia" Anesthesia and Anesthesia. 80 in press. (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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