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Pharmacology, physiology and clinical application of pregnancy-induced analgesia

Research Project

Project/Area Number 06671544
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionSAPPORO MEDICAL UNIVERSITY

Principal Investigator

IWASAKI Hiroshi  SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE DEPARTMENT OF ANESTHESIOLOGY,ASSOCIATE PROFESSOR, 医学部, 助教授 (70223386)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordspregnancy / endogenous analgesia / calcium channel blocker / カルシウムイオンチャンネル拮抗薬
Research Abstract

This is one of serires of studies to examine the physiology of pregnacy-induced analgesia in rats. The main purpose of this study was to examine the effects of 1-type calcium channel blockers on pregnancy-induced analgesia.
(1) This study was designed to investigate the effects of the intrathecal calcium channel blocker, verapamil, on the spinal anesthesia from lidacaine and tetracaine. Male Sprague-Dawley rats were chronically implanted with lumbar intrathecal catheters. Tail flick (TF) and mechanical paw pressure (MPP) tests were used to assess thermal and mechanical nociceptive threshold, respectively. Motor function was assessed using a modified Langerman's scale. Intrathecal lidocaine of tetracaine alone showed the prolongation of TF latency, the increase of MPP threshold, and the increase in motor function scale in a time-and dose-dependent manner. Although intrathecal verapamil alone demonstrated neither sensory nor motor block), the combination of lidocaine or tetracaine and ver … More apamil produced the more potent and prolonged antinociception and motor block when compared with local anesthetics alone. (2) We have studied the effects of three different types of calcium channel blockers (verapamil, diltiazem, and nicardipine) on local lidocaine sensory block. Standard tail flick (TF) test was employed to quantify the duration and dgree of local lidocaine-induced conduction block in rats. After obtaining baseline TF test, two 100mug of 0.3% lidocaine alone, a combination of verapamil, diltiazem, or nicardipine. and a large dose of calcium channel blockers were injected on opposite sites of the tail base. Coadministration of lidocaine and three doses of 1-type calcum channel blockers significant increases of antinociception at the level of the peripheral nerve. (3) The study was designed to examine the intrathecally administered calcium channel blocker, verapamil, on pregnancy-induced analgesia inrats. To assess thermal nociceptive threshold, tail flick test was emolyed. In pregnant rats, a significant increase in TF was demonstrated on late pregnancy. Intrathecally administered verapamil produced a significant prolongation of TF late in pregnancy. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Omotek, Iwasaki H et al.: "Effects of verapamil on spinal auehbesia with local cnestbetins." Auestbesia Analgesia. 80. 444-448 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Iwasaki H. et al.: "Potentiation of local lignocaine-induced sensory block by calcium channel blockers in rats." British Journal of Anaestbesia. 76(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Omotek, Iwasaki H. et al.: "Spinal antinoc ceptive action of an N-type voltage dependent calcium channel blecker and the syneigishc inferection" Anestbeclogy. 84(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Obmai H. Iwasaki, H. et al.: "Calcium channel blockers produce maikeel potentiation of local lidocane seusory block." Anestbeclogy. 81. A398 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 李潤子,岩崎寛他.: "妊娠に伴う内因性鎮痛に対するカルシウムチャンネル拮抗薬ベラパミルくも膜下投与の効果" Journal of Oneitheia. 9. A156 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Omote K,Iwasaki H,Kawamata M,Satoh O,Namiki A.: "Effects of verapamil on spinal anesthesia with local anesthetics." Anesthesia Analgesia. 80. 444-448 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Iwasaki H,Ohomori H,Omote K,Kawamata M,Sumita S,Yamauchi M,Namiki A.: "Potentiation of local lignocaine-induced sensory block by calcium channel blockers in rats.(in press.)" British Journal of Anaesthesia 199. 76.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Omote K,Kawamata M,Satoh O,Iwasaki H,Namiki A.: "Spinal antinociceptive action of an N-type voltage-dependent calcium channel blocker and the synergistic interaction with morphine." Anesthesilogy. 84(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohmori H,Iwasaki H,Omote K,Lee J,Namiki A.: "Calcium channel blockers produce marked potentiation of local lidocaine sensory block." 68th International Anesthesia Research Society Congress.Orland U.S.A.(1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J Lee, H Iwasaki, H Ohomori, K Omote, A Namiki.: "Potentiation of pregnancy-induced analgesia by intrathecally administered calcium channel blocker in rats." Journal of Anesthesia. A156. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 李澗子,岩崎寛他: "妊娠に伴う内因性鎮痛に対するカルシウムチャンネル拮抗薬ベラペミルのくも膜下投与の効果" Journal of Aneothesia. 9. A156 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Omote K,Iwasaki,H et al: "Effect of verapamil on spinal anesthesia with local anesthetics." Anesthesia and Analgesia. 80. 444-448 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Iwasaki,H.et al: "Potentiation of local lignocaine sensory block by calcium channel blockers in rat" British Journal of Anaesthesia. 76(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Omote K,Iwasaki H.et al.: "Spinal antinociceptive action of an N-type voltage-dependent calcium cahnnel blockers and the synergic interaction with morphine." Anesthesiology. 84(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohmori H,Iwasaki,H et al.: "Calcium channel blickers produce marked potentiation of local lidocaine sensory block." Anesthesiology. 81. A398- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大森英哉、岩崎 寛、他: "各種鎮痛薬の体性痛および内臓痛に対する鎮痛効果 1.モルヒネと非ステロイド性消炎鎮痛薬の比較検討" 麻酔. 43. 1310-1313 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩崎 寛、他: "各種鎮痛薬の体性痛および内臓痛に対する鎮痛効果 2.モルヒネ、ブプレノルフィンおよびペンタゾシンの比較検討" 麻酔. 43. 1648-1652 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Omote K,Iwasaki H et al.: "Effect of verapamil on spinal anesthesia with local anesthetics." Anesthesia analgesia. 8D. 444-448 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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