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Inhibitory effect of intravenous anesthetics and magesium on vascular and airway smooth muscles of the guinea-pig.

Research Project

Project/Area Number 06671549
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionJchi Medical School

Principal Investigator

KASUDA Haruyuki  Jichi Medical School, Dept of Anesthesiology, Associate Professor, 医学部, 助教授 (20090590)

Co-Investigator(Kenkyū-buntansha) YAMASHIRO T  Jichi Medical School, Dept of Anesthesiology, Research fellow, 医学部, 助手 (70265271)
TSUKAMOTO N  Jichi Medical School, Dept of Anesthesiology, Research fellow, 医学部, 助手
TOGASHI H  Jichi Medical School, Dept of Anesthesiology, Research fellow, 医学部, 助手 (80301456)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsvascular smooth muscle / airway smooth muscle / intravenous anesthetics / propofol / ketamine / thiopetal / magnesium / relaxation
Research Abstract

We examined the direct effect of propofol on contractile response and the modulating effect of propofol on electrically induced neurogenic contractions, using the guinea pig vascular and airway smooth muscles. Results indicate that, in a nonspecific way, propofol exhibited the relaxant effect on vascular and airway smooth muscles, and that the mechanism may mainly be on interference with opening of voltage-operated Ca^<2+> channels in the sarcolemma. It is suggested that propofol inhibited autonomic neurotransmission by decreasing norepinephrine released on postsynaptic membrane in vascular smooth muscle, whereas by decreasing neuropeptides released on presynaptic membranein airway smooth muscle.
We compared the direct effects of intravenous anesthetics and Mg on contractile response and the modulating effects them on electrically induced neurogenic contractions, using the guinea pig airway smooth muscles. Results indicate that, in a nonspecific way, they exhibited the relaxant effect on airway smooth muscle, and that the mechanisms may mainly be on interference with opening of voltage-operated Ca^<2+> channels when propofol, with Ca^<2+>-Releasing from SR when ketamine, and with the both when thiopental or Mg^<2+>. It is suggested that they inhibited autonomic neurotransmission. Mg^<2+>, ketamine and thiopental inhibited cholinergic, nonadrenergic and noncholinergic neurotransmisson, whereas propofol did not inhibit cholinergic neurtransmission.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Haruyuki Kasuda: "Different spasmolytic effects of propofol,ketamine and thiopental on airway smooth muscle contractions of the guinea-pig in vitro." 11th World Congress of Anaesthesiologists. (Abstract). 115 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "A comparative study of propofol and ketamine on pulmonary,vascular and airway smooth muscles of the guinea-pig in vitro." Journal of Anesthesia.10. 208 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 堀田訓久: "モルモット気道平滑筋収縮に対する3種類の静脈麻酔薬の比較" Journal of Anesthesia.10. 203 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Togashi: "Inhibitory effect of magnesium on autonomic neurotransmission of guinea-pig airway smooth muscle." Journal of Anesthesia.9. 238 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Togashi: "Inhibitory effect of magnesium on contraction of the guinea-pig isolated trachea and bronchus." Journal of Anesthesia.8. A61 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 粕田 晴之: "モルモット摘肺実質,肺動脈および気管支に対するpropofolの弛緩作用" 麻酔. 42. S582 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "Different spasmolytic effects of propofol, ketamine and thiopetal on airway smooth muscle contractions of the guinea-pig in vitro." 11th World Congress of Anaesthesiologists. Abstract : 115. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "A comparative study of propofol and ketamine on pulmonary, vascular and airway smooth muscles of the guinea-pig in vitro." Jounal of Anesthesia. 10. 208 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kunihisa Hotta: "Different spasmolytic effects of propofol, ketamine and thiopental on airway smooth muscle contractions of the guinea-pig in vitro" Jounal of Anesthesia. 10. 203 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Togashi: "Inhibitory effect of magnesium on autonomic neurotransmission of guinea-pig airway smooth muscle." Jounal of Anesthesia. 9. 238 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Tagashi: "Inhibitory effect of magnesium on contraction of the guinea-pig isolated trachea and bronchus" Jounal of Anesthesia. 8. A61 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "Inhibitory effect of propofol on pulmonary, vascular and airway smooth muscles." Masui. 42(10). S582 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "Inhibitory effect of propofol on vascular smooth muscles of the guinea-pig." Circulation Control. 14. 54 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "Inhibitory effect of propofol on airway smooth muscles of guinea-pig." Pharmacoanesthesiology. 5. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Haruyuki Kasuda: "Inhibitory effect of propofol on airway smooth muscles of guinea-pig." Pharmacoanesthesiology. 5. (1992)32-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kasuda H: "Different spasmolytic effects of propofol, ketmine and thiopental on airway smooth muscle contractions of the guinea-pig in vitro." 11th World Congress of Anaesthesiologists. 115 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kasuda H: "A comparative study of propofol and ketamine on pulmonary, vascular and airway smooth muscles of the guina-pig in vitro." Journal of Anesthesia. 10. 208 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hotta K: "モルモット気道平滑筋収縮に対する3種類の静脈麻酔薬の比較" Journal of Anesthesia. 10. 203 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Togashi H: "Inhibitory effect of magnesium on autonomic neurotransmission of guina-pig airway smooth muscle." Journal of Anesthesia. 9. 238 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Togashi,H: "Inhibitory effect of magnesium on contraction of the guinea-pig isolated trachea and bronchus." Journal A Anesthesia. 8. A61- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 粕田晴之: "麻酔・周術期とマグネシウム" 治療. 75. 951-957 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 富樫秀彰: "モルモット気道平滑筋の自律神経伝達に及ぼすマグネシウム濃度の影響" Journal of Amesthesia. 9. (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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