| Project/Area Number |
06671573
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | KYORIN UNIVERSITY |
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Principal Investigator |
NUTAHARA Kikuo Kyorin Univ., School of Med., Dept.of Urology, Associate Professor, 医学部, 助教授 (00143470)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHIHARA Eiji Kyorin Univ., School of Med., Dept.of Urology, Professor, 医学部, 教授 (00092312)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | PRIMARY HIPERPARATHYROIDISM. / ACID-BASE BALANCE. / BONE MINERAL DENSITY. / PTHmRNA. / VITAMIN D_3 RECEPTOR RNA / 電解質酸塩基平衡 / 原発性副甲状腺機能亢進症 / カルシウム代謝 / 酸塩基平衡 |
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| Research Abstract |
1. Renal bicarbonate metabolism in patients with primary hyperparathyroidism
This study evaluated the acid-base balance and renal handling of bicarbonate in ten patients with primary hyperparathyroidism before and after parathyroidectomy.
Renal tubular threshold of bicarbonate increased and fractional urinary bicarbonate excretion of the filtered load decreased after parathyroidectomy. However, no disturbances or changes in acid-base balance were observed before and after surgery.
2. Bone mineral density in patients with primary hyperparathyroidism
This study evaluated the bone mineral density in 15 patients with primary hyperparathyroidism before and after parathyroidectomy.
Bone mineral density decreased in the patient, with primary hyperparathyroidism of chemical and renal stone types. After surgery, bone mineral density of the skull and lumbar spine increased immediately. However, no changes in bone mineral density of the lower limbs were observed before and after surgery.
3. PTHmRNA and vitamin D_3 receptor RNA in primary hyperparathyroidism
Total RNA of the parathyroid gland could be measured in five patients with primary hyperparathyroidism (parathyroid adenomas). However, the measurement of the PTHmRNA and vitamin D_3 receptor RNA in parathyroid adenomas using Northern bolt methods were failed.
We conclude that primary hyperparathyroidism does not induce an acid-base disturbance, although the renal tubular threshold of bicarbonate is suppressed and fractional urinary bicarbonate excretion of filtered load is increased by excessiv endogenous PTH.Normal acid-base balance in primary hyperparathyroidism might be due to enhancement of extrarenal acid buffering capacyty (probably, bone).
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