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STUDIES ON RENAL KALLIKREIN-KININ SYSTEM IN EXPERIMENTAL HYDRONEPHROTIC RATS

Research Project

Project/Area Number 06671601
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOITA MEDICAL UMIVERSITY

Principal Investigator

MIZOGUCHI Hiroaki  OITA MEDICAL UNIVERSITY DEPARTMENT OF UROLOGY ASSISTANT PROFESSOR, 医学部, 講師 (40157524)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Shinichi  OITA MEDICAL UNIVERSITY DEPARTMENT OF UROLOGY ASSISTANT, 医学部, 助手 (40171491)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordshydronephrotic rat / renal kallikrein-kinin systrm / urinary kallikrein activity
Research Abstract

To examine a role on renal kallikrein-kinin system in experimental hydronephrotic rats, we measured urinary kallikrein activity before and after transient complete urinary obstruction. As a result, urinary kallikrein activity decreased during unilateral ureteral obstruction and slightly increased after removing obstruction. In bilateral ureteral obstuction for 24 hours, urinary kallikrein activity decreased for three days after removing obstruction. However, urinary kallikrein activity increased for the subsequent three days. In bilateral ureteral obstruction for 48 hours, urinary kallikrein activity remained to be decreased after removing obstuction. These findings suggest that renal kallikrein-kinin system may be suppressed during uranary obstruction and may be activated when urinary obstuction is removed in early phase. Further study is necessary to elucidate a role of renal kallikrein-kinin system in hydronephrosis.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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