| Project/Area Number |
06671602
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
OHI Yoshitada Kagoshima Univ., Faculty of Medicine, Professor, 医学部, 教授 (10041394)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Daishi Kagoshima Univ., Faculty of Medicine, Reseach Associate, 医学部, 助手 (70239838)
KAWAHARA Kazuya Kagoshima Univ., Faculty of Medicine, Reseach Associate, 医学部, 助手 (90204750)
KAWAHARA Motoshi Kagoshima Univ., Faculty of Medicine, Assistant Professor, 医学部, 講師 (40161351)
GOTO Toshihiro Kagoshima Univ., Faculty of Medicine, Associate Professor, 医学部, 助教授 (50128427)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Urinary tract infections / Biofilm bacteria / Pseudononas aeruginosa / Antimicrobials / Porin protein / In vivo models / 尿路留置カテーテル / バイオフィルム / 精巣上体炎 / 造精障害 / バイオフィルム菌 |
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| Research Abstract |
It was proved in rabbits that pyelonephritis could be prevented by the vaccination with porlin protein (Omp) of Escherichia coli in rabbits with a small size of inoculum of the organism. Opsonization of the organism by anti-Omp lgG in cooperation with the other immune system seemmed to be a main mechanism in the cases.
Both in vitro and in vivo models of catheter-associated urinary tract infections, fluoroquinolones among the antimicrobials tested showed most potent bactericidal activity against thebiofilm bacteria of Pseudomonas aeruginosa in urine. From the view point of the clinical situation, however, it may be difficult for the fluoroquinolones to erradicate biofilm bacteria of P.aeruginosa in many cases with urinary catheters. Though it has been reported in the patients with pulmonary infections that some types of macrorides enhenced bactericidal effects against the biofilm bacteria of P.aeruginosa, the addictive effect of macrorides was not evident in thepresent studies.
Experimental epididymitis or prostatitis were developed in rabbits or in rats through the inoculatin of bacteria into the vas or urethra, respectively. These models of infections may may be usefull for the investigation of the pathogenesis and treatment in human cases.
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