PATHOLOGICAL CLASSIFICATION AND CLINICAL SIGNIFICANCE OF BLADDER CANCER BASED ON MUTATION OF NUCLEAR ONCOGENE AND TUMOR SUPRESSOR GENE.
| Project/Area Number |
06671604
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | YOKOHAMA CITY UNIVERSITY |
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Principal Investigator |
NOGUCHI Sumio YOKOHAMA CITY UNIVERSITY,UROLOGY,ASSOCIATE PROFESSOR, 医学部・泌尿器科, 助教授 (40137047)
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| Co-Investigator(Kenkyū-buntansha) |
YAO Masahiro YOKOHAMA CITY UNIVERSITY,UROLOGY,ASSISTANT PROFESSOR, 医学部・泌尿器科, 講師 (00260787)
SHUIN Taro KOCHI MEDICAL COLLEGE,UROLOGY,PROFESSOR, 泌尿器科, 教授 (80179019)
KUBOTA Yoshinobu YOKOHAMA CITY UNIVERSITY,UROLOGY,ASSOCIATE PROFESSOR, 医学部・泌尿器科, 助教授 (10106312)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | NUCLEAR ONCOGENE / TUMOR SUPRESSOR GENE / BLADDER CANCER |
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| Research Abstract |
We investigate the roles and possible interactions of retinoblastoma (RB), transforming growth factor-beta 1 (TGF-beta1) and c-myc genes in bladder cancer. The expression of these 3 genes was examined in 38 biopsy specimens of human bladder cancer by immunohistochemical study and Northern blotting. Loss of the retinoblastome protein expression was most significantly correlated with high grade cancer. Over expression of c-myc or expression of TGF-beta1 was less associated with tumor grade or stage, although c-myc over expression defined stage Ta against other stage tumors, since no stage Ta lesions had increased c-myc expression. Finally, loss of RB gene function did not correlate with either c-myc or TGF-beta1 expression.
These results further support that RB gene inactivation is an important factor in the progression of bladder cancer, and suggest that TGF-beta1 and c-myc are not regulators or not regulated by RB gene expression.
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Report
(3 results)
Research Products
(16 results)
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[Publications] Miyamoto, H., Kubota, Y., Shuin, T., Torigoe, S., Hosaka, M., Iwasaki, Y., Danenberg, K.and Danenberg, P.: "Analysisof p53 mutation inprimary human bladder cancer." Oncology Research. 5. 245-249 (1993)
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[Publications] Kubota, Y., Miyamoto, H., Noguchi, S., Shuin, T., Kitamura, H., Xu, H.J.Hu, S.X.and Benedict, W.F.: "THe loss of retinoblastoma gene in association with c-myc and transforming growth factor- beta1 gene expression in" J.Urol. 154. 371-374 (1995)
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[Publications] Miyamoto, H., Kubota, Y., Shuin, T., Torigoe, S., Dobashi, Y.and Hosaka, M.: "Expression of transforming growth factor-beta 1 in human bladder Cancer." Cancer. 75. 2565-2570 (1995)
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