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PATHOLOGICAL CLASSIFICATION AND CLINICAL SIGNIFICANCE OF BLADDER CANCER BASED ON MUTATION OF NUCLEAR ONCOGENE AND TUMOR SUPRESSOR GENE.

Research Project

Project/Area Number 06671604
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionYOKOHAMA CITY UNIVERSITY

Principal Investigator

NOGUCHI Sumio  YOKOHAMA CITY UNIVERSITY,UROLOGY,ASSOCIATE PROFESSOR, 医学部・泌尿器科, 助教授 (40137047)

Co-Investigator(Kenkyū-buntansha) YAO Masahiro  YOKOHAMA CITY UNIVERSITY,UROLOGY,ASSISTANT PROFESSOR, 医学部・泌尿器科, 講師 (00260787)
SHUIN Taro  KOCHI MEDICAL COLLEGE,UROLOGY,PROFESSOR, 泌尿器科, 教授 (80179019)
KUBOTA Yoshinobu  YOKOHAMA CITY UNIVERSITY,UROLOGY,ASSOCIATE PROFESSOR, 医学部・泌尿器科, 助教授 (10106312)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
KeywordsNUCLEAR ONCOGENE / TUMOR SUPRESSOR GENE / BLADDER CANCER
Research Abstract

We investigate the roles and possible interactions of retinoblastoma (RB), transforming growth factor-beta 1 (TGF-beta1) and c-myc genes in bladder cancer. The expression of these 3 genes was examined in 38 biopsy specimens of human bladder cancer by immunohistochemical study and Northern blotting. Loss of the retinoblastome protein expression was most significantly correlated with high grade cancer. Over expression of c-myc or expression of TGF-beta1 was less associated with tumor grade or stage, although c-myc over expression defined stage Ta against other stage tumors, since no stage Ta lesions had increased c-myc expression. Finally, loss of RB gene function did not correlate with either c-myc or TGF-beta1 expression.
These results further support that RB gene inactivation is an important factor in the progression of bladder cancer, and suggest that TGF-beta1 and c-myc are not regulators or not regulated by RB gene expression.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Miyamoto,H.: "Analysis of p53 mutation in primary human bladder cancer" Oncology Research. 5. 245-249 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 窪田吉信: "泌尿器科領域における癌遺伝子.癌抑制遺伝子" 臨床泌尿器科. 48. 185-194 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kubota,Y.: "The loss of retinoblastoma gene in association with c-myc and transforming growth factor-β1 gene expression in human bladder cancer" Journal of Urology. 154. 371-374 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyamoto,H.: "Retinoblastoma gene mutation in primary human bladder cancer" British Journal of Cancer. 71. 831-845 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyamoto,H.: "Expression of transforming growth factor β1 in human bladder cancer" Cancer. 75. 2565-2570 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyamoto, H., Kubota, Y., Shuin, T., Torigoe, S., Hosaka, M., Iwasaki, Y., Danenberg, K.and Danenberg, P.: "Analysisof p53 mutation inprimary human bladder cancer." Oncology Research. 5. 245-249 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kubota, Y., Miyamoto, H., Uemura, H., Fujinami, K.and Shuin, T.: "Oncogene and tumor supressor gene in urological malignancies." Rinsho Hinyokika. 48. 185-194 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kubota, Y., Miyamoto, H., Noguchi, S., Shuin, T., Kitamura, H., Xu, H.J.Hu, S.X.and Benedict, W.F.: "THe loss of retinoblastoma gene in association with c-myc and transforming growth factor- beta1 gene expression in" J.Urol. 154. 371-374 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyamoto, H., Shuin, T., Torigoe, S., Iwasaki, Y.and Kubota, Y.: "Retinoblastoma gene mutation in primary human bladder cancer." Brit.L.Cancer. 71. 831-835 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyamoto, H., Kubota, Y., Shuin, T., Torigoe, S., Dobashi, Y.and Hosaka, M.: "Expression of transforming growth factor-beta 1 in human bladder Cancer." Cancer. 75. 2565-2570 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyamoto,H: "Analyses of P53 gene mutation in primary human bladder cancer" Oncology Research. 5. 245-249 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kubota,Y: "The loss of retinoblastoma gene in association with c-myc and transforming growth factor-β1gene expression in human bladder cancer" The Journal of Urology. 154. 371-374 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroshi Miyamoto: "Analyses of p53 Gene Mutations in Primary Himan Bladder Cancer" Oncology Research. 5. 245-249 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 窪田吉信: "尿路性器癌の発生と進展における癌遺伝子" 泌尿器外科. 6. 495-500 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshinobu Kubota: "The Loss of Retinoblastoma Gene in Association with c-myc and TGF-β1 Gene expression in Human Bladder Cancer" The Journal of Urology. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 窪田吉信: "泌尿器科領域における癌遺伝子,癌抑制遺伝子" 臨床泌尿器科. 48. 185-194 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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