| Project/Area Number |
06671629
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | THE UNIVERSITY OF TOKYO |
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Principal Investigator |
KOJIMA Toshiyuki TOKYO UNIVERSITY BRANCH HOSPITAL,FACULTY OF MEDICINE,THE UNIVERSITY OF TOKYO,Department of Obstetrics & Gynecology, Assistant Professor, 医学部・附属病院(分), 講師 (90153535)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANA Takashi TOKYO UNIVERSITY BRANCH HOSPITAL,FACULTY OF MEDICINE,THE UNIVERSITY OF TOKYO,Dep, 医学部・附属病院(分), 教授 (90010272)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | hepatitis C virus / transmisssion route / mother-to-child transmission / PCR / HCV RNA / virus genome / HCV / HCV抗体 / 垂直感染 / RT-PCR |
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| Research Abstract |
OBJECTIVE : Our purpose was to study the intrafamilial transmission of hepatitis C virus (HCV) and the mother-to-child transmission rate of HCV in babies born to HCV carrier mothers.
STUDY DESIGN : Anti-HCV antibody (anti-HCV) was tested for 2,528 consecutive pregnant women using an EIA first or second generation kit.Babies born to anti-HCV-positive mothers and their family members had their anti-HCV and HCV RNA checked.These babies were prospectively studied every 3 month till 1 year and thereafter every 6 month.
RESULTS : 1.19% of this population were positive for HCV.Eighteen of the 32 anti-HCV-positive pregnant women (56.3%) had HCV RNA.Six of 26 their husbands (23.1%), 4 of 21 of their mothers (19.0%) and 6 of 11 their fathers (54.5%) had anti-HCV,which were much higher prevalence rates than in the general population (p<0.001). Two among 30 samples of cord blood from babies born to these pregnant women (6.7%) had HCV RNA.Among 29 children born to 18 HCV RNA-positive pregnant women, 4 (13.8%) had HCV RNA,but none of 27 children born to 14 HCV RNA-negative pregnant women.
CONCLUSIONS : It is suggested that mother-to-child and intrafamilial transmission of HCV exists and that the route appears to be transplacental in 2 out of 4 cases.Mother-to-child transmission, including by the transplacental route, occurs and its rate may be from 5 to 15%.
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