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The clarification of anti-blood coagulation activity of human placental chorioepithelial brush border membrane

Research Project

Project/Area Number 06671677
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNARA MEDICAL UNIVERSITY

Principal Investigator

AKADA Shinobu (1995-1996)  NARA MEDICAL UNIVERSITY,OBSTET.& GYNECOL., ASSISTANT, 医学部, 助手 (30231806)

飯岡 秀晃 (1994)  奈良県立医科大学, 医学部, 講師 (10183154)

Co-Investigator(Kenkyū-buntansha) 赤田 忍  奈良県立医科大学, 医学部, 助手 (30231806)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Keywordsanti-coagulation / anti-platelet aggregation / placenta / brush border membrane / ADP / EPH-gestosis / brush border / platelet / heparin / ATIII / ADP
Research Abstract

During pregnancy, blood coagulability and platelet aggreability are enhanced. On the other hand, human placental chorioepithelial brush border membrane which is in direct contact with material blood flow, possesses anti-blood coaglation and anti-platelet aggregatiion activity. We investigated anti-platelet aggregation activity in human placental brush border membrane and its changes in EPH-gestosis. We also investigated anti-coagulation activity in human placental brush border membrane and obtained the following results.
A) Human placental brush border membrane posseses potent ADP degrading activity which is closedly related to anti-platelet aggregation activity. We succeeded in partial purification of this ADP degrading enzyme.
B) The inhibiting activity of placental brush border membrane against platelet aggregation induced by ADP (adenosine diphosphate) and the ADP degrading activity of placental brush border membrane, decreased prominently compared to control in severe EHP-gestosis. Thus is was indicated that this damaging of anti-platelet aggregation activity in brush border membrane closely related to the pathology of placental dysfunction in EPH-gestosis.
C) We clarified the existence of heparin like activity in human placental brush border membrane, and partially characterized this heparin like activity.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 赤田 忍: "ヒト胎盤絨毛上皮の血小板凝集阻止機構-刷子縁膜の血小板凝集阻止活性の妊娠経過による変化-" 産婦人科の進歩. 46(6). 689-697 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 赤田 忍: "胎盤絨毛上皮の血液凝固抑制機能と胎盤微小循環" 日本妊娠中毒症学会雑誌. 3. 67-70 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] "Studies on platelet aggregation inhibition of human placental syncytiotrophoblast brush border membrane-role of alhaline phosphatase" Placenta. 15. 91-121 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 赤田忍: "ヒト胎盤絨毛上皮の血小板凝集阻止機構-刷子縁膜の血小板凝集阻止活性の妊娠経過による変化-" 産婦人科の進歩. 48(6). 689-697 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 赤田忍: "胎盤絨毛上皮の血液凝固抑制機能と胎盤微小循環" 日本妊娠中毒症学会雑誌. 3. 67-70 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 飯岡秀晃: "胎盤絨毛刷子縁膜の血液凝固制御" 日本産婦・新生児血液誌. 4. 5-6 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飯岡秀晃 他6名: "胎盤絨毛刷子縁膜の血小板凝集阻止活性の妊娠経過による変化" 日本産婦・新生児血液誌. 4. 21-22 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Iioka H.et al.: "Studies on placental inhibition of platelet aggregation of human placental syncytio trophoblast -role of alkaline phosphatase" Placenta. 15. 291-298 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飯岡秀晃 他6名: "妊娠時の血小板機能の変化-コレステロールが血小板凝集に与える影響" 臨婦産. 48. 1033-1036 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飯岡秀晃 他5名: "胎盤絨毛組織の抗トロンビン活性" 日本産婦・新生児血液誌. 4. 25-26 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飯岡秀晃 他4名: "胎盤絨毛組織のADP分解活性の特性" 日本産婦・新生児血液誌. 4. 23-24 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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