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Inhibitory response of locus coeruleus neurons to caloric stimulation in rats

Research Project

Project/Area Number 06671712
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionOsaka University

Principal Investigator

TAKEDA Noriaki  Osaka Univ.Med.Cch., Dept.of Otolaryngology, Assist.Prof., 医学部, 講師 (30206982)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Shoji  Yamaguchi Univ.Med.Sch., Dept.of Physiology, Prof., 医学部, 教授 (80112051)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordslocus coeruleus / Caloric stimulation / Vestibulo-autonomic reflex / GABA / Ventrolateral medulla / ラット / VLM / 前庭自律神経反射 / カロリー刺激
Research Abstract

We examined the effects of caloric vestibular stimulation on the neuronal activity of the locus coeruleus (LC) in urethane-anesthetized rats. The middle ear cavity was irrigated with hot (44゚C) or cold (30゚C) water through a polyethylene tube. Most neurons exhibited suppression of neuronal discharge in response to caloric stimulation. The suppression of LC neuronal discharge following caloric stimulation occured with a long latency and lasted a long period of time (about 3 min). Neither caloric stimulation of the auricle, nor irrigation of the middle ear with water at 37゚C,nor caloric stimulation of the middle ear after labyrinthectomy inhibited LC neuronal discharge. The caloric stimulation-induced LC neuronal inhibition was attenuated by the iontophoretic applocation of bicuculline. These findings indicate that the predominant effect of caloric stimulation on LC neuronal discharge is inhibitory, and that the caloric stimulation-induced LC ncuronal in inhibition is mediated by GABA_A receptors. We then examined the effects of lesions in the rostral vcntrolateral medulla (VML) or in the nucleus prepositus hypoglossi (PrII) on LC neuronal inhibition caused by caloric stimulation. VML lesions attenuated caloric stimulation-induced LC neuronal inhibition, but PrII lesions did not. This finding indicates that vestibular inhibition of LC neurons is mediated by VML.It is suggested that the suppressed activity of noradrenergic LC neurons is involved in the vestibulo-autonomic reflex.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Nishiike S.,et al.: "Responses of locus coeruleus neurons to caloric stimulation in rats." Acta Oto-Laryngol. Suppl.520. 105-109 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishiike S. et al.: "Effects of caloric vestibular stimulation on prespositus hypogloss neurons in rats." Eur. Arch. Otorhinolaryngol.253. 52-56 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishiike S. et al.: "GABAergic inhibitory response of locus coeruleus neurons to caloric vestibular stimulation in rats." Brain Res.(In press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishiike S.,et al.: "Vestibular inhibition of locus coeruleus noradrenergic system." Jpn. J. Physiol.(In press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Nishiike, et al.: "GABAergic inhibitory response of locus coeruleus neurons to caloric stimulation in rats." Brain Research. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Nishiike, et al.: "Effects of caloric vestibular stimulation on prepositus hypoglossi neurons in rats." Eur.Arch.Otorhnolaryngol. 253. 52-56 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Nishiike, et al.: "Vestibular inhibition of locus coeruleus noradrenergic system" Jpn.J.Pyhsiol.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishiike S.et al.: "Responses of locus coeruleus neurons to caloric stimulation in rats." Acta Oto-Laryngol.Suppl.520. 105-109 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishiike S.et al.: "Effects of caloric vestibular stimulation on prespositus hypogloss neurons in rats." Eur.Arch.Otorhinolaryngol.253. 52-56 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishiike S.et al.: "GABA ergic inhibitory response of locus coeruleus neurons to calori vestibular stimulation in rats." Brain Res.(In press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishiike S.et al.: "Vestibular inhibition of locus coeruleus noradrenergic system." Jpn.J,Physiol.(In press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishiike S.et al.: "Responses of locus coeruleus neurons to caloric stimulation in rats." Acta Oto-Laryngol.Suppl.(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishiike S.et al.: "Responses of locus coeruleus neurons to caloric vestibular stimulation." Neurosci.Res.Suppl.18. S194- (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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