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IMMUNOLOGICAL AND EPSTEIN-BARR VIROLOGICAL STUDIES OF LETHAL MIDLINE GRANULOMA

Research Project

Project/Area Number 06671728
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionSAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

HARABUCHI Yasuaki  SAPPORO MEDICAL UNIVERSITY,SHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (80208686)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsLETHAL MIDLINE GRANULOMA / NASAL T-CELL LYMPHOMA / POLYMORPHIC RETICULOSIS / EPSTEIN-BARR VIRUS / IMMUNOLOGY / VIROLOGY / 進行性鼻壊疸 / 免疫学
Research Abstract

Clinicalphenotypicand genotypic features and the association with Epstein-Barr virus (EBV) of 18 patients with nasal T-cell lymphoma of lethal midline granuloma type (NTL-LMG) were investigated. The clinical features were characterized as prolonged fever (16 patients), widespread dissemination into distant sites (13 patients), and poor prognosis with median survival of only 6 months. EBV-encoded small nuclear early region (EBER) transcripts were identified in 16 of 18 patients. Monoclonal EBV genome, EBV-encoded nuclear antigen type 1 (EBNA1), and latent membrane protein type 1 (LMP1), were detected also in all EBER-positive cases tested. All 18 patients expressed pan-T antigens such as MT1, CD45RO,and/or CD2. The rearrangements of T-cell receptor (TCR)-beta, -gamma and/or -delta genes were shown in all 11 tumors tested. The natural killer (NK) cell phenotype, CD56, was expressed in all EBV-positive cases tested, and was not detected in EBV-negative cases. Seven EBV-positive cases expressed TCR-delta chain with rearranged TCR-gamma or -delta gene. While, all 2 EBV-negative cases corresponded to alphabetaT-cell lymphoma, which represented TCR-beta chain with rearranged TCR-beta gene. These data suggest that EBV-positive NTL-LMG may be derived from the lineage of NK-like T-cell or gammadeltaT-cells, and that EBV may play a role in the lymphomagenesis. Therefore, we propose that NTL-LMG which have peculiar clinical and histological features could be classified into a new lymphoma entity.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Harabuchi Y, et al.: "Immunophenotypic and immuno genotypic studies of lethalmidline granuloma associated with Epstein-Barr virus." Immurohiology in Otolaryngology. Progress of a decade. Kugler Publication, Amsterdam. 591-593 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 形浦昭克,原渕保明: "進行性鼻壊疸(鼻性T細胞リンパ腫)の本態と臨床" 耳鼻咽喉科展望. 38. 541-565 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Harabuchi Y, et al: "Circulating intercellular adhesion molecule-1(ICAM-1)and its cellular expression in head and neck non-Hodgkin's lyaphomas inclnding lethal midline granuloma." Annals Oto Rhino Laryngol. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Harabuchi Y, et al: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus:Clinicopathologic, phevotypic, and geuotypic studies." Cancer. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Harabuchi Y,Kataura A,Imai S,Osato T.: "Immunophenotypic and immunogenotypic studies of lathal midline granuloma associated with Epstein-Barr virus.G.Mogi, J.E.Veldman and H.Kawauchi (ed) Immunobiology in Otalaryngology." Progress of a decade.Kugler Publications, Amsterdam.591-3 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Harabuchi Y,Kataura A,Imai K.: "Circulating intercellular adhesion molecule-1 (ICAM-1) and its cellular expression in head and neck non-Hodgkin's lymphomas including lethal midline granuloma." Annals Ota Rhino Laryngol. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Harabuchi Y,Imai S,Wakashima J,Hirao M,Kataura A,Osato T,Kon S.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus : Clinicopathologic, phenotypic, and genotypic studies." Cancer (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 形浦昭克,原渕保明: "進行性鼻壊疸(鼻性T細胞リンパ腫)の本態と臨床" 耳鼻咽喉科展望. 38. 541-565 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Harabuchi Y,et al.: "Circulating intercellular adhesion molecule-1(ICAM-1)and its cellular expression in head and neck non-Hodgkin's lymphomasincluding lethal midline grenuloma" Annals Oto Rhino Laryngol. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Harabuchi Y,et al.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus:Clin:copathologic,phenotypic,and genotypic studies." Cancer. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Minarovits,J.,Hu,LF.,Imai,S.,Harabuchi,Y.et al.: "Clonarity,expression and methylation patterns of the Epstein-Barr virus genomes in lethal midline granulomas classified as peripheral angiocentric T cell lymphomas" J.Gen.Viol. 75. 77-84 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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