| Project/Area Number |
06671742
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
KUMAZAWA Hirobumi KANSAI MEDICAL UNIVERSITY Faculty of Medicine Asistant Professer, 医学部, 講師 (80148519)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAI Shin-ichi KANSAI MEDICAL UNIVERSITY Faculty of Medicine Research Associate, 医学部, 助手 (30195961)
TACHIKAWA Takuya KANSAI MEDICAL UNIVERSITY Faculty of Medicine Research Associate, 医学部, 助手 (30216981)
KAWAMOTO Keiji KANSAI MEDICAL UNIVERSITY Faculty of Medicine Professer, 医学部, 教授 (70077741)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
|
|---|
| Keywords | apoptosis / chemotherapy / head and neck cancer / apoptosis / 頭頚部癌 |
|---|
| Research Abstract |
Apoptosis is a specific mode of cell death characterized by morphological, biological and molecular changes. Cell death by apoptosis is common in normal tissues and with organ involution and in cytotoxic immunological reactions. This mode of cell death in neoplastic tissues has recently become a focus of interest. Since little is known of apoptosis inhead and neck tumors, we studied the morphological changes in head and neck tumor-derived cell lines (KB,KBrc, HSC-2,3,4) in the in vitro experimental assay. Furthermore, we tried to use the apoptotic reaction for overcoming CDDP resistance. In the in vivo model, which we developed using nude mouse model, we observed CDDP resistance after multiple application of 254-S.However, the apoptotic reaction did not overcome the resistance of 254-S in tumor cells.
|
