| Project/Area Number |
06671754
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
YAMAMOTO Shuichi Toyama Medcal and Pharmaceutical University School of Medicine, Associate Professor, 医学部, 助教授 (20230550)
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| Co-Investigator(Kenkyū-buntansha) |
ONOZU Hiroyuki Toyama Medcal and Pharmaceutical University Hospital, Assistant, 附属病院, 助手 (90262526)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Retinal transplantation / Transgenic mouse / Retinal dystrophic mouse / Retinal dystrophic rat / Immunosuppression / 網膜視細胞移植 / 異種間移植 / 視細胞外節 |
|---|
| Research Abstract |
Photoreceptors from normal neonatal or transgenic neonatal mice with normally daveloping retinas were transplanted into the subretinal spaces of normal rats. The animals with transplants received either immunosuppressive treatment with tacrolimus hydrate (FK506) for the first two weeks after transplantation or no treatment. At four weeks after transplantation, graft survival occurred only in rats treated with tacrolimus. In 7 of the 12 treated eyes, photoreceptors survived at least four weeks after transplantation. Relatively mature outer segments were found only in two eyes in which the retinal grafts formed rosettes.
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