| Project/Area Number |
06671788
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
小児外科
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| Research Institution | Chiba University |
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Principal Investigator |
TANABE Masahiro INSTITUTION,DEPARTMENT,TITLE OF POSITION : CHIBA UNIVERSITY SCHOOL OF MEDICINE,LECTURER, 医学部付属病院, 講師 (10207160)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | neuroblastoma / bone marrow metastasis / bone metastasis / murine neuroblastoma / 化学療法 |
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| Research Abstract |
To elucidate the development of bone metastasis in human neuroblastoma, bone marrow and bone metastases were analyzed histologically in a hematogeneous metastasis model of murine neuroblastoma. The bone marrow metastasis occurred initially in the bone marrow sinusoid where tumor cells adhered and extravasated to bone marrow parenchyma, resulting in the formation of nodular lesions in the medullary cavity. The nodular lesions eventually progressed to diffuse lesions segmentally occupying the medullary cavity. During the establishment of the diffuse lesions, tumor cells invaded cancellous bone and/or bone cortex, resulting in bone metastasis. Such nodular or diffuse bone marrow metastatic lesions occurred sporadically in a variety of bones. To improve the results of treatment for neuroblastoma, the characteristics of the bone marrow and the bone metastases demonstrated in this study should beconsidered in the diagnosis and treatment of this disease.
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